ʻO Pexidartinib

Anter

• Ma mua o ka lawe ʻana i ka pexidartinib,
• Hoʻokumu paha ʻo Pexidartinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hiki i ka Pexidartinib ke kumu i ka hōʻino ʻana o ke ake. E haʻi i kāu kauka inā loaʻa ʻoe i ka maʻi maʻi ate. E haʻi i kāu kauka a me ka mea kauka lāʻau e pili ana i nā lāʻau āu e lawe nei i hiki iā lākou ke nānā inā paha e hoʻonui i kekahi o kāu lāʻau i ka makaʻala e hoʻomohala ʻoe i ka hōʻino o ke ake i kou wā e mālama ai me pexidartinib Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: ka luhi nui loa, ka nalo ʻana o ka makemake, ka pohō kaumaha, kahoʻi, ka luaʻi, ke kahe ʻana a kahe ʻana o ka ʻili, ka melemele o ka ʻili a me nā maka, ka mimi melemele a me nā kala ʻeleʻele. , a i ʻole ʻeha ma ka ʻaoʻao ʻākau i luna o ka ʻōpū. Pono paha i kāu kauka e hōʻemi i kāu lāʻau o pexidartinib a i ʻole kūmau manawa a kūloko paha i kāu lāʻau.

Ua hoʻonohonoho ʻia kahi papahana i kapa ʻia ʻo Turalio Risk Evaluation and Mitigation Strategy (REMS) e mālama i nā pilikia o kēia lāʻau. Hiki ke loaʻa iā ʻoe ka pexidartinib inā ʻoe a me ke kauka nāna i kuhikuhi i kāu lāʻau i kākau inoa ʻia ka papahana. Hiki iā ʻoe ke loaʻa i ka lāʻau lapaʻau wale nō mai kahi kauka i komo i ka papahana. E nīnau i kāu kauka inā he nīnau paha kāu e pili ana i ke komo ʻana i ka papahana a pehea e loaʻa ai kāu lāʻau.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha aku kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kou wā o ka mālama ʻana e hōʻoia he palekana ia no ʻoe e lawe i ka pexidartinib a e nānā i ka pane o kou kino i ka lāʻau.

E hāʻawi aku kāu kauka a mea kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me ka pexidartinib a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i ka pexidartinib.

Hoʻohana ʻia ʻo Pexidartinib e mālama ai i nā tumors cell giant tenosynovial (TGCT; nā tumors a i ʻole a puni kahi hui e hiki ai ke hōʻeha, pehu, a hoʻemi i ka neʻe) i nā mākua i hiki ʻole ke mālama ʻia e ke ʻoki. Aia ʻo Pexidartinib i kahi papa o nā lāʻau i kapa ʻia nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kahi protein pono ʻole i hiki ke kōkua i ka tumo e holoholo.

Hele mai ʻo Pexidartinib ma ke ʻano he capsule e lawe ma ka waha. Lawe ʻia ia i ʻelua mau manawa i kēlā me kēia lā ma kahi ʻōpū hakahaka ma ka liʻiliʻi he 1 hola ma mua a i ʻole 2 mau hola ma hope o ka pāʻina a me ka meaʻai māmā. E lawe i ka pexidartinib ma kahi o ka manawa like (s) i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E lawe pono i ka pexidartinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā capsule holoʻokoʻa; mai wehe, nau, a wāwahi paha iā lākou.

Inā ʻoe e luaʻi ma hope o ka lawe ʻana i ka pexidartinib, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka pexidartinib,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka pexidartinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā capsule pexidartinib. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E haʻi pono i kekahi o kēia mau mea: clarithromycin (Biaxin, i Prevpac); kekahi mau antifungals e like me itraconazole (Onmel, Sporanox) a i ʻole ketoconazole; enzalutamide (Xtandi); kekahi mau lāʻau no ka maʻi pale maʻi (HIV) a i ʻole loaʻa i ka maʻi maʻi maʻi maʻi (AIDS) e like me efavirenz (Sustiva, i Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ma Kaletra), a saquinavir (Hoʻokele); modafinil (Provigil); nefazodone; pioglitazone (Actos, ma Duetact, Oseni); probenecid (Probalan); nā mea pale proton-pump e like me esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), a me rabeprazole (AcipHex); rifabutin (Mycobutin); rifampin (Rifadin); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Equetro, Tegretol, Teril), phenobarbital, a me phenytoin (Dilantin, Phenytek); aiʻole nā ​​steroid oral e like me dexamethasone, methylprednisolone (Medrol), a me prednisone. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me ka pexidartinib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• inā ʻoe e lawe i nā antacids i loaʻa ka magnesium a i ʻole ka alumini (Maalox, Mylanta, Tums, a me nā mea ʻē aʻe), e lawe i ka antacid i 2 mau hola ma mua a ma ka liʻiliʻi he 2 mau hola ma hope o kou lawe ʻana i ka pexidartinib.
• inā ʻoe e lawe i kahi lāʻau no ka palaka ʻana, ka puʻuwai, a i ʻole nā ​​maʻi ulcer e like me cimetidine (Tagamet), famotidine (Pepcid, in Duexis), nizatidine (Axid), a i ʻole ranitidine (Zantac), lawe ma ka liʻiliʻi he 10 mau hola ma mua a i ʻole 2 paha. mau hola ma hope o kou lawe ʻana i ka pexidartinib.
• e haʻi i kāu kauka a me kāu kauka lāʻau he aha nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St. ʻAʻole pono ʻoe e lawe i ka wort a St. John i kou wā e mālama ai me ka pexidartinib.
• e haʻi i kāu kauka inā loaʻa ʻoe a i ʻole loaʻa i ka maʻi maʻi kidney.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i ka hānau keiki ʻana. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o kou hoʻomaka ʻana i ka mālama ʻana a hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā lapaʻau a no 1 mahina ma hope o kāu hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā e hoʻohana i ka kaohi hānau i ka wā o kāu mālama ʻana me ka pexidartinib a no 1 hebedoma ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Hiki i ka Pexidartinib ke hoʻemi i ka momona i nā kāne a me nā wahine. Eia nō naʻe, ʻaʻole pono ʻoe e kuhi ʻaʻole hiki iā ʻoe a i ʻole kāu pakanā ke hāpai. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana i ka pexidartinib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Pexidartinib i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana ʻoe i ka pexidartinib a no 1 mau pule ma hope o kāu hopena hope loa.

Mai ʻai i ka nui o ka huaʻulu a inu paha i ka wai huaʻikuʻi i ka wā e lawe ana i kēia lāʻau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Pexidartinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• loli ke oho lauoho
• hoʻololi i ka ʻono
• luhi
• kōpaʻa

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• hūwī
• ʻūlili
• pehu o nā lima, nā wāwae, nā wāwae a me nā kuʻekuʻe wāwae
• ʻeha ma nā lima a me nā wāwae
• pehu a puni ka maka

Hiki i ka Pexidartinib ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua. Mai wehe i ka desiccant (pepa liʻiliʻi i hoʻopili ʻia me ka lāʻau e omo i ka waiū) mai ka ʻōmole, inā i hāʻawi ʻia kekahi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Turalio^®