Mea Kākau: Gregory Harris
Lā O Ka Hana: 8 Apelila 2021
HōʻAno Hou I Ka Lā: 18 Nowemapa 2024
Anonim
The Mechanism of Action (MOA)
Wikiō: The Mechanism of Action (MOA)

Anter

Hiki i ka Deutetrabenazine ke hoʻonui i ka makaʻu o ke kaumaha a i ʻole nā ​​manaʻo suicidal (e noʻonoʻo e pili ana i ka hōʻino ʻana a pepehi paha iā ʻoe iho a i ʻole ke hoʻolālā ʻana a i ʻole ke hoʻāʻo ʻana e hana pēlā) i ka poʻe me ka maʻi o Huntington (kahi maʻi hoʻoilina e hoʻokumu i ka haʻihaʻi holomua o nā pūnana nerve i ka lolo). E haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha iā ʻoe kahi kaumaha a inā he manaʻo paha kāu e pili ana i ka hōʻino a pepehi ʻana iā ʻoe iho. Inā loaʻa ʻoe i ka maʻi o Huntington a kaumaha a i ʻole he manaʻo suicidal paha, e ʻōlelo paha kāu kauka iā ʻoe ʻaʻole e lawe i ka deutetrabenazine. ʻO ʻoe, kou ʻohana, a mea mālama paha e kāhea koke aku i kāu kauka inā ʻike ʻoe i kekahi o nā hōʻailona aʻe: ke kaumaha hou a i ʻole ke kaumaha paha, nā manaʻo e pili ana i ka hōʻeha a pepehi paha iā ʻoe iho a i ʻole ke hoʻolālā ʻana a hoʻāʻo ʻana paha e hana pēlā, hopohopo nui, hoʻonāukiuki, pilikia hiamoe a i ʻole noho hiamoe, hana ʻino a kolohe paha, huhū, hana me ka noʻonoʻo ʻole, hoʻomaha nui ʻole, hopohopo, loli i ke kaumaha o ke kino, nalowale o ka hoihoi i ka launa pū ʻana, paʻakikī i ka nānā ʻana, a i ʻole nā ​​hoʻololi ʻē aʻe o ka lawena. E nānā pono i kou ʻohana a mea mālama paha e nānā iā ʻoe i nā manawa āpau a ʻike i nā hōʻailona e koʻikoʻi paha i hiki iā lākou ke kāhea i ke kauka inā ʻaʻole hiki iā ʻoe ke ʻimi iā ʻoe lāʻau ponoʻī.


Mālama i nā manawa āpau me kāu kauka. E makemake paha kāu kauka e kamaʻilio pū me ʻoe e pili ana i kou olakino noʻonoʻo ke lawe nei ʻoe i kēia lāʻau.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka pepa ʻikepili a ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me deutetrabenazine a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Hoʻohana ʻia ʻo Deutetrabenazine e mālama i ka chorea (neʻe hikiwawe i hiki ʻole iā ʻoe ke kāohi) i hoʻokumu ʻia e ka maʻi o Huntington (kahi maʻi hoʻoilina e hoʻokumu i ka haki holomua o nā hunaola nerve i ka lolo). Hoʻohana ʻia ia e mālama i ka diskinesia tardive (ka neʻe ʻole o ka helehelena, ke alelo, a i ʻole nā ​​ʻāpana kino ʻē aʻe). Aia ʻo Deutetrabenazine i loko o ka papa o nā lāʻau i kapa ʻia nā mea kāohi ʻo vesicular monoamine transporter 2 (VMAT2). Hana ia ma ka hoʻololi ʻana i ka hana o kekahi mau mea kūlohelohe i ka lolo e hoʻopili i nā aʻalolo a me nā mākala.


Hele mai ʻo Deutetrabenazine ma ke ʻano he papa e lawe ma ka waha. No nā mea maʻi me ka maʻi o Huntington, lawe mau ʻia me ka meaʻai i hoʻokahi manawa i ka lā i ka mua a laila hoʻonui ʻia i ʻelua mau manawa i ka lā. No nā mea maʻi me ka diskinesia lohi, lawe mau ʻia ia me ka meaʻai i ʻelua mau lā. Lawe iā deutetrabenazine ma kahi o ka manawa like (s) i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E lawe pololei i ka deutetrabenazine. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi lāʻau haahaa o deutetrabenazine a hoʻonui iki i kāu lāʻau, ʻaʻole ʻoi aku i hoʻokahi manawa i kēlā me kēia pule.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.


Ma mua o ka lawe ʻana i ka deutetrabenazine,

  • e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka deutetrabenazine, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa deutetrabenazine. Hana ia ma ka hoʻololi ʻana i ka hana o kekahi mau mea kūlohelohe i ka lolo. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka inā ʻoe e lawe ana i ka reserpine, tetrabenazine (Xenazine), valbenazine (Ingrezza), a i ʻole kahi monoamine oxidase (MAO) mea kāohi e like me isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl , Emsam, Zelapar), a me tranylcypromine (Parnate), a i ʻole inā ua oki ʻoe i ka lawe ʻana i kahi mea hoʻopuka monoamine oxidase i loko o nā pule he 2 i hala a i ʻole ua oki i ka lawe ʻana i ka reserpine i nā lā he 20 i hala. E haʻi paha kāu kauka iā ʻoe ʻaʻole pono ʻoe e lawe i ka deutetrabenazine.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E kuhikuhi pono i kekahi o kēia: nā lāʻau no ka hopohopo; antidepressants e like me bupropion (Aplenzin, Wellbutrin, Zyban), fluoxetine (Prozac, Sarafem, Selfemra), a me paroxetine (Brisdelle, Paxil, Pexeva); antipsychotics e like me chlorpromazine, haloperidol (Haldol), olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal), thioridazine, a me ziprasidone (Geodon); kekahi mau lāʻau no nā puʻuwai kūlike ʻole e like me amiodarone (Nexterone, Pacerone), procainamide, quinidine (i Nuedexta), a me sotalol (Betapace, Sorine, Sotylize); moxifloxacin (Avelox); nā lāʻau no ke kaohi ʻana; nā mea hoʻonanea, nā lāʻau moe, a i ʻole nā ​​mea hoʻomaluhia. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi i kāu kauka inā loaʻa ʻoe i ka maʻi ate. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka deutetrabenazine.
  • e haʻi i kāu kauka inā loaʻa a i ʻole loaʻa iā ʻoe kahi QT maʻi lōʻihi (ke ʻano e hoʻonui i ka makaʻu o ka hoʻomohala ʻana i kahi puʻuwai kūwaho ʻole e hiki ai ke maule a hōʻeha paha i ka make) a i ʻole kekahi ʻano o ka puʻuwai puʻuwai ʻole a i ʻole ka pilikia o ka puʻuwai puʻuwai. E haʻi aku i kāu kauka inā he haʻahaʻa kou i ke koko o ka magnesium a i ʻole ka potassium i kou koko a i ʻole ka maʻi ʻaʻai umauma.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka deutetrabenazine, e kāhea i kāu kauka.
  • pono ʻoe e ʻike ʻo ka deutetrabenazine e hiamoe ai ʻoe a e hoʻoluhi ai hoʻi i ka luhi. Mai hoʻokele i kahi kaʻa a hana i nā mīkini a ʻike ʻoe i ka hopena o kēia lāʻau iā ʻoe.
  • pono ʻoe e ʻike hiki i ka waiʻona ke hoʻohui i ka hiamoe i hoʻokumu ʻia e kēia lāʻau.Mai inu i ka waiʻona i ka wā e lawe ana i ka deutetrabenazine.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Inā makemake ʻoe e lawe i ka deutetrabenazine ma mua o hoʻokahi pule, e kamaʻilio me kāu kauka ma mua o ka hoʻomaka ʻana e lawe hou. E hoʻomaka hou paha ʻoe i ka lawe ʻana i kahi mahele haʻahaʻa.

Hoʻokumu paha ʻo Deutetrabenazine i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • pāhoehoe
  • kōpaʻa
  • waha maloo
  • luhi
  • ʻeha a ʻā paha i ka urination
  • ʻāpala
  • maʻi hanu o luna

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e hoʻōki i ka lawe ʻana i ka deutetrabenazine a kāhea koke aku i kāu kauka a i ʻole e kiʻi i nā lāʻau lapaʻau pilikia

  • ke kuni, ka hou ʻana, ka huikau, ka wikiwiki o ka puʻuwai puʻuwai a i ʻole kaulike, a me ka ʻīʻī nui o nā io
  • luliluli, ʻoʻoleʻa, a paʻakikī paha i ka neʻe a mālama ʻana paha i kāu kaulike
  • hāʻule
  • kuʻi ʻole a i ʻole kūpikipiki wikiwiki
  • maule ana

Hoʻokumu paha ʻo Deutetrabenazine i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a mamao aku mai ka mālamalama, ka wela a me ka momona o ka wela (ʻaʻole i loko o ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

  • wili a kekeʻe paha i nā neʻe
  • neʻe wikiwiki ʻana o ka maka
  • nausea
  • ka luaʻi
  • ka houʻu ʻana
  • hoʻomālie
  • huikau
  • pāhoehoe
  • hallucination (ke ʻike nei i ka mea a i ʻole ka lohe ʻana i nā leo i ʻole)
  • ʻulaʻula o ka ʻili
  • luliluli ʻole

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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