ʻO Osimertinib

Anter

• Ma mua o ka lawe ʻana i osimertinib,
• Hiki iā Osimertinib ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Osimertinib e pale i kekahi ʻano maʻi ʻaʻai liʻiliʻi liʻiliʻi ʻole (NSCLC) mai ka hoʻi ʻana ma hope o ka hemo ʻana o ka tumo e ka ʻoki ʻana i nā mākua. Hoʻohana ʻia ia ma ke ʻano he lapaʻau mua no kekahi ʻano NSCLC i hoʻolaha ʻia i nā ʻāpana ʻē aʻe o ke kino i ka poʻe mākua. Hoʻohana ʻia ʻo Osimertinib e mālama i kekahi ʻano o ka NSCLC i hoʻolaha ʻia i nā ʻāpana ʻē aʻe o ke kino i nā mākua i hiki ʻole ke mālama kūleʻa ʻia me nā lāʻau chemotherapy like like. Aia ʻo Osimertinib i kahi papa o nā lāʻau i kapa ʻia nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o ka protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hōʻoki a hoʻolohi paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai a kōkua i ka hōʻemi i nā tumors.

Hele mai ʻo Osimertinib ma ke ʻano he papa e lawe ma ka waha. Lawe pinepine ʻia me ka ʻai ʻole a ʻai ʻole hoʻokahi manawa i ka lā. Aia ka lōʻihi o kāu mālama ʻana i ka maikaʻi o ka hana ʻana o kēia lāʻau iā ʻoe, a me nā hopena ʻaoʻao āu e ʻike ai. Lawe iā osimertinib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka osimertinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Inā ʻaʻole hiki iā ʻoe ke ale i nā papa, waiho i ka papa i 4 mau punetēpu (2 oz [60 mL]) o ka wai a hoʻowali a hiki i ka papa i nā ʻāpana liʻiliʻi. Inu koke ka hui ʻana. E ninini i kahi kīʻaha ʻehā (4 oz [120 mL]) i kahi kīʻaha wai (8 oz [240 mL]) i ka ipu āu i hoʻohana ai, holoi, a inu e ʻike pono i loaʻa ka piha piha o ka osimertinib. Mai hoʻohana i ka wai kalapona a i ʻole nā ​​wai ʻē aʻe e hoʻonā i ka papa osimertinib. Mai haki i ka papa ʻaina a wela i ka hui. Inā loaʻa iā ʻoe kahi paipu nasogastric (NG), e wehewehe kāu kauka a mea kauka paha pehea e hāʻawi ai i kēia hui ma o kahi Tube.

Hiki i kāu kauka ke hoʻopau i kahi manawa kūlohelohe a paʻa paha i kāu lāʻau lapaʻau a hoʻoliʻiliʻi paha i kāu mahele lāʻau o osimertinib ma muli o nā hopena i loaʻa iā ʻoe. E kamaʻilio pono i kāu kauka e pili ana i kou ʻano i kou wā e mālama ai. Mai hōʻoki i ka lawe ʻana i osimertinib me ke kamaʻilio ʻole ʻana me kāu kauka.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i osimertinib,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka osimertinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka papa osimertinib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi aku i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻaiʻai āu e lawe nei a hoʻolālā paha e lawe. E haʻi pono i kekahi o kēia mau mea: anagrelide (Agrylin); trioxide arsenic (Trisenox); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); chloroquine (Aralen); chlorpromazine; cilostazol (Pletal); citalopram (Celexa); donepezil (Aricept); escitalopram (Lexapro); haloperidol (Haldol); nā lāʻau naʻau a i ʻole ke kaomi koko; methadone (Dolophine, Methadose); oxaliplatin (Eloxatin); phenytoin (Dilantin, Phenytek); pimozide (Orap); quinidine (i Nuedexta); rifampin (Rifadin, Rimactane, ma Rifamate, Rifater); rosuvastatin (Crestor); sulfasalazine (Azulfidine); thioridazine; topotecan (Hycamtin); a vandetanib (Caprelsa). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Hiki paha i nā lāʻau ʻē aʻe ke launa pū me osimertinib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka wort a St. John ʻoiai e lawe ana i ka osimertinib.
• e haʻi i kāu kauka inā loaʻa a i ʻole loaʻa iā ʻoe kahi QT maʻi lōʻihi (ke ʻano e hoʻonui ai i ka makaʻu o ka hoʻomohala ʻana i kahi puʻuwai puʻuwai ʻole e hoʻonāwaliwali ai ʻole make koke paha); he kuʻi puʻuwai kūpono ʻole; maikaʻi ʻole o ka puʻuwai (kahi e hiki ʻole ai i ka puʻuwai ke pauma i ke koko i nā ʻāpana ʻē aʻe o ke kino); ʻoi aku ke kiʻekiʻe a i ʻole haʻahaʻa ma mua o nā pae maʻamau o ka sodium, potassium, calcium, a me magnesium i loko o kou koko; nā pilikia o ka maka; a i ʻole nā ​​kūlana lung.
• pono ʻoe e ʻike i ka osimertinib e hoʻemi i ka momona i nā kāne a me nā wahine. Eia nō naʻe, ʻaʻole pono ʻoe e kuhi ʻaʻole hiki iā ʻoe a i ʻole kāu pakanā ke hāpai. E haʻi i kāu kauka inā hāpai ʻoe, a i ʻole hoʻolālā e hāpai. Pono ʻoe e lawe i kahi hōʻike hāpai ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a ʻaʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i ka osimertinib. E hoʻohana i ka kaohi hānau kūpono i kāu mālama ʻana me osimertinib, a no 6 mau pule ma hope o kāu hopena hope loa. Inā he kāne ʻoe a hiki i kāu pakanā ke hāpai, pono ʻoe e hoʻohana i ka kaohi hānau pono i kou wā e mālama ai a no 4 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana iā osimertinib, e kāhea koke i kāu kauka. Hiki iā Osimertinib ke hōʻeha i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. E haʻi paha kāu kauka iā ʻoe ʻaʻole e hānai i ka waiū i kou wā e mālama ai a no 2 mau pule ma hope o kāu hopena hope loa.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau i ka hopena a lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki iā Osimertinib ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• pāhoehoe
• kōpaʻa
• hūwī
• ʻūlili
• ʻili maloʻo a ʻū paha
• eczema
• nausea
• ka luaʻi
• nalo ʻai ʻole
• pehu a ʻeha paha i ka waha
• ʻeha kua
• Hoʻololi ke kui me ka pehu ʻana, ʻulaʻula, ʻeha, hoʻokaʻawale ʻana, wāwahi ʻana, a me ka hoʻokaʻawale a nalowale ʻana paha mai ke kui

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• wikiwiki, a i ʻole kuʻi ka puʻuwai puʻuwai; pokole o ka hanu; ka pehu ʻana o nā kuʻekuʻe wāwae a i ʻole nā ​​wāwae, a i ʻole ke ʻā ʻana o ka uila
• kuni; ka hanu hou hou a maikaʻi ʻole paha; pilikia i ka hanu ʻana, a i ʻole ka tale
• ʻili a ʻili paha
• nā kiko poni, ʻulaʻula, a i ʻole nā ​​hives ma nā lima, nā wāwae o lalo, a i ʻole nā ​​kī
• ʻeha ka umauma
• luhi loa
• pehu, ʻulaʻula, haehae a ʻeha paha nā maka; ʻike i ka mālamalama; a i ʻole hoʻololi i ka hihiʻo

Hiki iā Osimertinib ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha aku kāu kauka i kekahi mau hoʻokolohua hana puʻuwai ma mua a i kou wā o ka mālama ʻana e hōʻoia he palekana ia no ʻoe e lawe i ka osimertinib, a e nānā i ka pane o kou kino i ka lāʻau. Hiki paha i kāu kauka ke kauoha i kahi hoʻokolohua lab ma mua o kou hoʻomaka ʻana i kāu lāʻau e ʻike inā hiki ke mālama ʻia i kou maʻi ʻaʻai me osimertinib.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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