Mea Kākau: Joan Hall
Lā O Ka Hana: 4 Pepeluali 2021
HōʻAno Hou I Ka Lā: 1 Iulai 2025
Anonim
Arsenic Trioxide as Initial Therapy for Acute Promyelocytic Leukemia | Memorial Sloan Kettering
Wikiō: Arsenic Trioxide as Initial Therapy for Acute Promyelocytic Leukemia | Memorial Sloan Kettering

Anter

E hāʻawi wale ʻia ka Arioic trioxide ma lalo o ke kiaʻi ʻana a ke kauka i loaʻa ka ʻike i ka mālama ʻana i ka poʻe i loaʻa ka leukemia (maʻi ʻaʻai o nā hunaola keʻokeʻo).

Hiki i ka Arsenic trioxide ke kumu i kahi hui koʻikoʻi a hoʻoweliweli paha i ke ola o nā ʻōuli i kapa ʻia ʻo APL ʻokoʻa ʻokoʻa. E nānā pono kāu kauka iā ʻoe e ʻike inā ke hoʻomohala nei ʻoe i kēia maʻi maʻi. E noi paha kāu kauka iā ʻoe e kaupaona iā ʻoe iho i kēlā me kēia lā i loko o nā mau pule mua o kou mālama ʻana no ka mea ʻo ka loaʻa ʻana o ke kaupaona kahi hōʻailona o ka maʻi ʻokoʻa APL. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: ke kuni, ke kaupaona, ka hanu ʻana, ka hanu hana ʻana, ka ʻeha o ka umauma, a me ka uha paha. I ka hōʻailona mua ke hoʻomohala nei ʻoe i ka maʻi ʻokoʻa APL, e kau kauka i hoʻokahi a ʻoi paha nā lāʻau e mālama ai i ka maʻi maʻi.

Hiki i ke Arioic trioxide ke hoʻolōʻihi i ka QT (ʻoi aku ka lōʻihi o nāʻiʻo o ka puʻuwai ma waena o nā kuʻi ma muli o ka haunaele uila), i hiki ai ke hōʻeha i nā pilikia puʻuwai puʻuwai koʻikoʻi a hoʻoweliweli paha. Ma mua o kou hoʻomaka ʻana i ka lāʻau me ka trioxide arsenic, e kauoha kāu kauka i kahi electrocardiogram (ECG; hōʻike e hoʻopaʻa i ka hana uila o ka puʻuwai) a me nā hoʻokolohua ʻē aʻe inā ʻike ʻoe i kahi haunaele uila i kou puʻuwai a i ʻoi aku paha ma mua o ka makaʻu maʻamau o ke hoʻomohala nei i kēia ʻano. E nānā pono kāu kauka iā ʻoe a e kauoha iā ECG a me nā hoʻokolohua ʻē aʻe i kou wā e mālama ai me trioxide arsenic. E haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe ka hoʻolōʻihi ʻana o QT, maikaʻi ʻole o ka puʻuwai, kūpikipikiʻole o ka naʻau, a i ʻole nā ​​pae haʻahaʻa o ka potassium a me ka magnesium i kou koko. E haʻi aku i kāu kauka inā e lawe ana ʻoe i kekahi o nā lāʻau aʻe: amiodarone (Nexterone, Pacerone), amphotericin (Abelcet, Amphotec, Fungizone), cisapride (Propulsid), disopyramide (Norpace), diuretics ('pills wai'), dofetilide ( Tikosyn), erythromycin (EES, E-Mycin, Erythrocin), moxifloxacin (Avelox), pimozide (Orap), procainamide (Procanbid, Pronestyl), quinidine (Quinidex), sotalol (Betapace, Betapace AF), sparfloxacin (Zarfloxacin) (Mellaril), a me ka ziprasidone (Geodon). Kāhea koke aku i kāu kauka inā loaʻa kou puʻuwai kīnā ʻole a wikiwiki paha a inā e maule ʻoe i kou wā e mālama ai me trioxide arsenic.


Hoʻokumu paha ka injection Arioic trioxide i ka encephalopathy (huikau, nā pilikia hoʻomanaʻo, a me nā pilikia ʻē aʻe i hoʻokumu ʻia e ka hana lolo ʻole). E haʻi i kāu kauka inā inu ʻoe a inu paha i ka nui o ka wai ʻona, inā loaʻa ʻoe i ka maʻi maʻi malabsorption (pilikia e ʻimi ana i ka meaʻai), kahi hemahema meaʻai, a inā ʻoe e lawe nei i ka furosemide (Lasix). Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka: huikau; nalowale o ka ʻike; ka hopu ʻana; loli ke kamaʻilio ʻana; nā pilikia me ka laulima, ke kaulike, a me ka hele wāwae paha; a i ʻole nā ​​hoʻololi ʻike e like me ka hoʻemi ʻana i ka ʻike maka, nā pilikia heluhelu, a i ʻole ka ʻike lua. E ʻike pono i kou ʻohana a mea mālama paha e ʻike i nā hōʻailona e koʻikoʻi paha i hiki iā lākou ke ʻimi i ka lāʻau inā ʻaʻole hiki iā ʻoe ke kāhea iā ʻoe iho.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua ma mua a ma hope e nānā i ka pane o kou kino i ka arsenic trioxide.

E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana i arioic trioxide.


Hoʻohana ʻia ka trioxide arsenic me ka tretinoin e mālama ai i ka leukemia promyelocytic huikau (APL; kahi ʻano maʻi ʻaʻai e nui ai nā aʻa koko liʻiliʻi ʻole i loko o ke koko a me ka iwi iwi) i kekahi poʻe ma ke ʻano he lapaʻau mua. Hoʻohana ʻia ia e mālama iā APL i kekahi mau kānaka i kōkua ʻole ʻia e nā ʻano chemotherapy ʻē aʻe a i ʻole i hoʻomaikaʻi ʻia ke kūlana akā laila ua ʻoi aku ka maikaʻi ma hope o ka mālama ʻana me retinoid a me nā ʻano chemotherapy (s). ʻO Arsenic trioxide i loko o ka papa o nā lāʻau i kapa ʻia anti-neoplastics. Hana ia ma ka hoʻolohi a paʻa ʻana paha i ka ulu ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Arsenic trioxide ma ke ʻano he hopena (wai) e hoʻopili ʻia i loko o ke aa e ke kauka a kahu wahine paha i kahi keʻena olakino a i ʻole kahi keʻena lapaʻau. Hoʻokomo pinepine ʻia ʻo Arsenic trioxide ma mua o 1 a 2 mau hola, akā hiki ke ʻī ʻia ma kahi o 4 mau hola inā ʻike ʻia nā hopena ʻē aʻe i ka wā o ka infusion. Hāʻawi pinepine ʻia hoʻokahi manawa i ka lā no kahi manawa kikoʻī o ka manawa.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.


Ma mua o ka loaʻa ʻana o ka injection arioic trioxide,

  • e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka arsenic trioxide, i nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea i loaʻa i ka arsenic trioxide injection. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻai, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe E ʻōlelo pono i nā lāʻau i helu ʻia i ka ʻARlelo Aʻo IMPORTANT. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi ate a me nā puʻupaʻa.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i kahi keiki i kahi keiki. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o ka hoʻomaka ʻana o ka mālama ʻana a hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā lapaʻau a no 6 mau mahina ma hope o kāu hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā wahine e hoʻohana i ka kaohi hānau pono ke loaʻa ʻoe i ka injection arioic trioxide a no 3 mau mahina ma hope o ka hopena hope loa. Inā hāpai ʻoe a ʻo kāu hoa paha i ka hoʻohana ʻana i kēia lāʻau, e kāhea i kāu kauka. E kamaʻilio me kāu kauka e pili ana i ka hoʻohana ʻana i ka kaohi hānau e pale ai i ka hāpai ʻana i ka wā o kāu mālama ʻana me trioxide arsenic. Hoʻopilikia paha ka Arioic trioxide i ka fetus.
  • e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū.E haʻi paha kāu kauka iā ʻoe ʻaʻole e hānai i ka wā o kāu mālama ʻana a no 2 mau pule ma hope o kāu hopena hope loa.
  • pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka loaʻa ʻana o trioxide arsenic.
  • inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o ka niho, e haʻi i ke kauka a i ʻole kauka niho paha ke loaʻa nei iā ʻoe ka trioxide arsenic.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Hiki i ka arsenic trioxide injection ke hoʻonui i kāu kō kō. Kāhea koke i kāu kauka inā loaʻa iā ʻoe kekahi o nā ʻōuli o hyperglycemia (ke kō kiʻekiʻe).

  • make wai loa
  • urination pinepine
  • pōloli loa
  • nāwaliwali
  • ʻike hihi

Inā ʻaʻole mālama ʻia ke kō kō kiʻekiʻe, hiki i kahi ʻano koʻikoʻi, hoʻoweliweli ke ola i kapa ʻia he ketoacidosis diabetic ke ulu. E mālama koke i ka lāʻau inā loaʻa iā ʻoe kekahi o kēia mau ʻōuli.

  • waha maloo
  • nausea a me ka luaʻi
  • pokole o ka hanu
  • hanu ʻaʻala ʻaʻala
  • hoʻemi i ka ʻike

Hiki i nā kuʻina trioxide arsenic ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • luhi nui loa
  • ʻūpā
  • ʻeha poʻo
  • pāhoehoe
  • ka pehu ʻana o nā lima, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a i nā wāwae lalo
  • hūwī
  • ʻūlili

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻ sectionlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka:

  • ʻāpā ʻaʻano ʻole a hoʻokahe koko paha
  • ka luaʻi koko a i ʻole ke nānā aku e like me ke kahua kope
  • ʻōpala i ʻeleʻele a hoʻolohi a loaʻa paha i ke koko ʻulaʻula ʻulaʻula
  • hoʻemi urination
  • hives

Hiki i nā kuʻina trioxide arsenic ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Pākuʻi ʻia paha nā ʻōuli o ka overdose:

  • ka hopu ʻana
  • nāwaliwali o nā mākala
  • huikau

E nīnau i kāu kauka a kauka paha inā he nīnau paha kāu e pili ana i ka inikona arioic trioxide.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • ʻO Trisenox®
Nānā Hou - 08/15/2019

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