Bosentan

Anter

• Ma mua o ka lawe ʻana i ka bosentan,
• Hiki i ka Bosentan ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. ʻAʻole ʻike pinepine ʻia nā ʻōuli aʻe, akā inā ʻike ʻoe i kekahi o lākou a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i nā lāʻau lapaʻau pilikia.
• Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

No nā mea maʻi kāne a wahine paha:

Hiki i ka Bosentan ke hoʻopōʻino i ke ake. E haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi ate. E kauoha kāu kauka i kahi hoʻokolohua koko e ʻike pono ke hana maʻamau nei kou akepaʻa ma mua o kou hoʻomaka ʻana i ka bosentan a i kēlā me kēia mahina i kāu mālama ʻana. E mālama i nā manawa a pau me kāu kauka a me ka hale hana. Hiki iā Bosentan ke hoʻopōʻino i ke akepaʻa ma mua o ka hana ʻana i nā hōʻailona. ʻO nā hoʻokolohua koko maʻamau wale nō ke ala e ʻike ai i ka hōʻino o ke ake ma mua o ka lilo ʻana i paʻa a koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: nausea, luaʻi, fiva, ʻeha o ka ʻōpū, melemele o ka ʻili a me nā maka, a i ʻole ka luhi nui. Hiki i kāu kauka ke hōʻemi i kāu lāʻau, a i ʻole manawa kūmau a paʻa mau paha i kāu mālama ʻana me ka bosentan inā ʻike ʻoe i nā hopena a i ʻole nā ​​hopena lab.

No nā maʻi wahine:

Mai lawe i ka bosentan inā hāpai ʻoe a hoʻolālā paha e hāpai. Hoʻopilikia paha ʻo Bosentan i ka fetus. Inā hiki iā ʻoe ke hāpai, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o ka hoʻomaka ʻana i ka lāʻau, i kēlā me kēia mahina i ka wā o ka mālama ʻana, a no 1 mahina ma hope o kāu mālama ʻana e hōʻike ʻaʻole ʻoe hāpai. Kauoha kāu kauka i nā hoʻokolohua hāpai ou. Pono ʻoe e hoʻohana i kahi ʻano hilinaʻi o ka kaohi hānau i kāu wā lapaʻau a no 1 mau mahina ma hope o kāu lapaʻau. ʻAʻole hiki ke hana maikaʻi nā mea pale Hormonal (nā lāʻau kaohi hānau, nā pāhoʻi, nā apo, nā paʻi, nā implant, a me nā hāmeʻa intrauterine) ke hoʻohana ʻia me ka bosentan a pono ʻole e hoʻohana ʻia ma ke ʻano he ʻano hana wale no kou kaohi hānau. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu. I ka hapanui o nā hihia e koi ʻia ʻoe e hoʻohana i ʻelua mau ʻano o ka kaohi hānau.

Kāhea koke aku i kāu kauka inā he moe kolohe ʻole kou, e noʻonoʻo ʻole ua maikaʻi ʻole kāu kaohi hānau ʻana, e haʻalele i kahi wā a e manaʻo paha he hāpai ʻoe ʻoiai ʻoe e lawe ana i ka bosentan. Mai kali a hiki i kāu koho hou ʻana e kūkākūkā i kēia me kāu kauka.

Inā he makua a kahu paha ʻoe no ka mea maʻi wahine ʻaʻole i oʻo i ka wā ʻōpio, e nānā pinepine i kāu keiki e ʻike inā ke ulu nei ʻo ia i nā ʻōuli o ka ʻōpio (ʻōpuʻu umauma, lauoho pubic) a hōʻike i kāna kauka e pili ana i nā loli.

Ma muli o nā pilikia o ka hōʻino o ke ake a me nā kīnā o ka hānau ʻana, loaʻa wale ka bosentan ma o kahi papahana i kaupalena ʻia i kapa ʻia ʻo Tracleer Risk Evaluation and Mitigation Strategy Program (Tracleer REMS). I mea e loaʻa ai ka bosentan iā ʻoe a me kāu kauka e pono e hoʻopaʻa inoa me Tracleer REMS, a hāhai i nā papahana e pono ai e like me hoʻokahi manawa i ka mahina ka hana ate a me ka hoʻāʻo ʻana o ka hāpai ʻana. E hoʻopaʻa inoa kāu kauka iā ʻoe i ka papahana. Loaʻa wale ʻo Bosentan ma kekahi mau hale kūʻai lāʻau i hoʻopaʻa inoa ʻia me Tracleer REMS. E noi i kāu kauka a kauka paha inā he nīnau kāu e pili ana pehea e hoʻopiha ai i kāu kuhikuhi.

E loaʻa iā ʻoe ka pepa ʻikepili o ka mea hoʻomanawanui (Medication Guide) ke hoʻomaka ʻoe i ka lāʻau me bosentan a i kēlā me kēia manawa e hoʻopiha hou i ka palapala. E heluhelu pono i ka ʻike i kēlā me kēia manawa a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke loaʻa i ke Alakaʻi Medication mai ka pūnaewele FDA: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i ka bosentan.

Hoʻohana ʻia ʻo Bosentan i mea e mālama ai i ka hanu pulmonary hypertension (PAH, ke koko kiʻekiʻe i loko o nā moku e hāpai i ke koko i nā akemāmā) i nā mākua a me nā keiki he 3 mau makahiki a ʻoi paha. Hiki i ka Bosentan ke hoʻomaikaʻi i ka hiki ke hoʻoikaika kino a hoʻolōʻihi i ka hōʻino ʻana o nā ʻōuli i nā mea maʻi me PAH. Aia ʻo Bosentan i kahi papa o nā lāʻau i kapa ʻia he endagonhel receptor antagonists. Hana ia ma ka hoʻōki ʻana i ka hana o endothelin, kahi mea kūlohelohe e hoʻoliʻiliʻi ai nā kīʻaha koko a pale i ke kahe o ke koko maʻamau i ka poʻe i loaʻa iā PAH.

Hele mai ʻo Bosentan ma ke ʻano he papaha a ma ke ʻano he papa hoʻolahalaha (papa e hiki ke hoʻoheheʻe ʻia i ka wai) e lawe ma ka waha. Lawe mau ʻia me ka ʻai ʻole a i ʻole ʻelua mau manawa i ka lā i ke kakahiaka a me ke ahiahi. E kōkua iā ʻoe e hoʻomanaʻo e lawe i ka bosentan, e lawe ma kahi o nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pololei i ka bosentan e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Inā ʻoe e lawe ana i ka papa hoʻolahalaha, waiho i ka papa i kahi wai liʻiliʻi ma mua pono o kou lawe ʻana. Inā ua haʻi aku kāu kauka iā ʻoe e lawe i kahi papa hapalua, e haki pono i ka papa kaola puehu ma ka laina. Lawe i ka hapalua papa e like me ke kuhikuhi, a hoʻihoʻi i ka hapalua i ka blister i wehe ʻia i ka pūʻolo. E hoʻohana i ka papa ʻāpana ʻē aʻe i loko o 7 mau lā. Mai uhaʻi i ka papa hoʻolahalaha i mau ʻāpana.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi haʻahaʻa o bosentan a hoʻonui i kāu lāʻau ma hope o 4 mau pule.

Mālama ʻo Bosentan i nā ʻōuli o PAH akā ʻaʻole ia e hoʻōla iā ia. He 1 a 2 mau mahina paha a ʻoi paha ka lōʻihi ma mua o kou ʻike ʻana i ka pono piha o bosentan. E hoʻomau i ka lawe ʻana i ka bosentan inā ʻoe e ʻoluʻolu. Mai hōʻoki i ka lawe ʻana i ka bosentan me ke kamaʻilio ʻole ʻana me kāu kauka. Inā kū koke ʻoe i ka lawe ʻana i ka bosentan, eʻoi aku ka maikaʻi o kāu mau ʻōuli. Hiki i kāu kauka ke hōʻemi i kāu lāʻau.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka bosentan,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka bosentan, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o ka papa bosentan a i ʻole nā ​​papa hoʻolele.
• mai lawe i ka cyclosporine (Gengraf, Neoral, Sandimmune) a i ʻole glyburide (DiaBeta, Glynase) ʻoiai e lawe ana i ka bosentan.
• e haʻi i kāu kauka a me ka mea lapaʻau i nā lāʻau lapaʻau a me nā lāʻau ʻole ʻē aʻe, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei. E haʻi pono i kekahi o kēia mau mea: amiodarone (Nexterone, Pacerone); nā lāʻau hoʻohaʻahaʻa kolesterol (statins) e like me atorvastatin (Lipitor, ma Caduet), lovastatin (Altoprev), a me simvastatin (Flolopid, Zocor, i Vytorin); diltiazem (Cardizem, Cartia, Diltzac, nā mea ʻē aʻe); erythromycin (E.E.S., Eryc, PCE); fluconazole (Diflucan); gemfibrozil (Lopid); itraconazole (Onmel, Sporanox); ketoconazole; rifampin (Rifadin, Rimactane, ma Rifater, Rifamate); ritonavir (Norvir, ma Kaletra, Viekira Pak, Technivie); voriconazole (Vfend); a me warfarin (Coumadin, Jantoven). Pili pū paha nā lāʻau ʻē aʻe he nui me bosentan, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā loaʻa a i ʻole loaʻa paha ʻoe i ka puʻuwai puʻuwai (kahi e hiki ʻole ai i ka puʻuwai ke pauma i ke koko i nā ʻāpana ʻē aʻe o ke kino).
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū a i ʻole hoʻolālā e hānai. E haʻi paha kāu kauka iā ʻoe ʻaʻole e hānai i ka wā e lawe ana iā bosentan.
• inā loaʻa iā ʻoe ka phenylketonuria (PKU, kahi ʻano hoʻoilina e pono ai e ukali ʻia kahi papaʻai kūikawā e pale ai i ka noʻonoʻo ʻole o ka noʻonoʻo), pono ʻoe e ʻike ua ʻono ʻia nā papa hoʻolahalaha me ka aspartame, kahi kumu o phenylalanine.

E kamaʻilio me kāu kauka e pili ana i ka inu ʻana i ka wai huaʻomaʻo i ka lawe ʻana i kēia lāʻau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i ka Bosentan ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻeha poʻo
• ʻōhinu
• ihu ihu, ʻāʻī ʻāʻī, a me nā ʻōuli anu
• ʻeha pū

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. ʻAʻole ʻike pinepine ʻia nā ʻōuli aʻe, akā inā ʻike ʻoe i kekahi o lākou a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i nā lāʻau lapaʻau pilikia.

• hives; ʻehu; ʻumeʻume; pilikia i ka hanu ʻana a i ʻole ke ale ʻana; pehu o ka maka, puʻu, alelo, lehelehe, a me nā maka; hoarseness; kuni; pehu nā lymph node; luhi
• ka pehu ʻana o nā wāwae, nā kuʻekuʻe wāwae, a i ʻole nā ​​wāwae lalo, ka loaʻa ʻana o ke kaupaona, ʻoi aku ka pilikia me ka hanu ma mua o ka maʻamau
• ka hanu hou hou a maikaʻi ʻole paha; hou me ka worsening ʻūhā me a i ʻole me ke koko ʻole; ʻeha ka umauma; wikiwiki, kuʻi, a i ʻole kuʻi puʻuwai puʻuwai
• maule ana
• ʻūpā; ʻili mae; pokole o ka hanu; nāwaliwali; wikiwiki, kuʻi, a i ʻole kuʻi puʻuwai puʻuwai

ʻO nā holoholona laboratorium kāne i hāʻawi ʻia i nā lāʻau e like me ka bosentan i hoʻomohala i nā pilikia me kā lākou testicle a hana i nā sperm liʻiliʻi (nā kāne reproductive cells) ma mua o ka maʻamau. ʻAʻole ʻike ʻia inā e hōʻino ka bosentan i ka testicle a hoʻemi paha i ka helu o ka sperm i hana ʻia i nā kāne. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana i ka bosentan inā makemake ʻoe e loaʻa nā keiki i ka wā e hiki mai ana.

Hoʻokumu paha ʻo Bosentan i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

• ʻeha poʻo
• nausea
• ka luaʻi
• puʻuwai wikiwiki
• maule ana
• ka houʻu ʻana
• ʻūpā
• ʻike hihi

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka i kāu nīnau e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Tracleer^®