17-Hydroxyprogesterone

Anter

• He aha ka hōʻike 17-hydroxyprogesterone (17-OHP)?
• No ke aha ia e hoʻohana ai?
• No ke aha wau e pono ai i kahi hōʻike 17-OHP?
• He aha ka hana i ka wā o ka hoʻāʻo 17-OHP?
• Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?
• Aia kekahi mau pilikia i ka hoʻāʻo?
• He aha ke ʻano o nā hopena?
• Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i kahi hōʻike 17-OHP?
• Nā kūmole

He aha ka hōʻike 17-hydroxyprogesterone (17-OHP)?

Ana kēia hōʻike i ka nui o 17-hydroxyprogesterone (17-OHP) i ke koko. 17-OHP kahi hōmona i hana ʻia e nā adrenal glands, ʻelua mau gland ma luna o nā puʻupaʻa. Hana nā ʻōpū adrenal i kekahi mau hormones, e like me cortisol. He mea nui ʻo Cortisol no ka mālama ʻana i ke koko, ke kō a me nā hana o ka ʻōnaehana pale. Hana ʻia ʻo 17-OHP ma ke ʻano he mahele o ke kaʻina hana o ka hana ʻana i ka cortisol.

Kōkua kahi hōʻike 17-OHP i ke kuhi hewa ʻana i kahi maʻi kūlohelohe i kapa ʻia ʻo hyperplasia adrenal congenital (CAH). I CAH, kahi loli kūlohelohe, ʻike ʻia ma ke ʻano he mutation, pale i ka gland adrenal mai ka hana ʻana i ka nui o ka cortisol. Ke hana ikaika nei nā ʻōpū adrenal e hana hou i ka cortisol, hana lākou i 17-OHP keu, a me kekahi mau homone kāne kāne.

Hiki i ka CAH ke hoʻoulu i nā hanana kino a me nā ʻano moekolohe. ʻO nā ʻōuli o ka maʻi mai ke akahai a i ʻole koʻikoʻi. Inā mālama ʻole ʻia, hiki i nā ʻano ʻoi loa o ka CAH ke hana i nā pilikia koʻikoʻi, e like me ka make wai, ke koko haʻahaʻa, a me nā puʻuwai puʻuwai (arrhythmia).

Nā inoa ʻē aʻe: 17-OH progesterone, 17-OHP

No ke aha ia e hoʻohana ai?

Hoʻohana pinepine ʻia kahi hōʻike 17-OHP e ʻike pono iā CAH i nā keiki hānau hou. Hoʻohana ʻia paha ia i:

• Hōʻailona CAH i nā keiki makua a me nā mākua i loaʻa paha kahi ʻano milder o ka maʻi. I ka CAH māmā, hōʻike ʻia nā ʻōuli ma hope i ke ola, a i ʻole kekahi manawa ʻaʻole loa.
• Nānā i ka mālama ʻana no CAH

No ke aha wau e pono ai i kahi hōʻike 17-OHP?

Pono kāu pēpē i kahi hoʻokolohua 17-OHP, ma waena o 1-2 mau lā ma hope o ka hānau ʻana. Koi ʻia ka 17-OHP no CAH e ke kānāwai ma ke ʻano he ʻāpana o ka loiloi hou hānau. ʻO kahi kānana hānau hou kahi hōʻike koko maʻalahi e nānā ai no nā ʻano maʻi ʻino.

Pono paha nā keiki ʻelemakule a me nā mākua i ka hoʻāʻo inā loaʻa iā lākou nā ʻōuli o CAH. E ʻokoʻa nā ʻōuli ma muli o ka nui o ka maʻi, ka makahiki ke ʻike ʻia nā hōʻailona, ​​a inā he kāne a wahine paha ʻoe.

Hōʻike pinepine ʻia nā ʻōuli o ke ʻano ʻoi loa o ka maʻi ma waena o 2-3 mau pule ma hope o ka hānau ʻana.

Inā hānau ʻia kāu pēpē ma waho o ʻAmelika Hui Pū ʻIa a ʻaʻole i loaʻa iā lākou kahi kānana hānau hou, pono paha lākou e hoʻāʻo inā loaʻa iā lākou kekahi a ʻoi paha o nā hōʻailona aʻe.

• Nā genital ʻaʻole maopopo he kāne a wahine paha (ambiguous genitalia)
• Make wai
• ʻO ka luaʻi a me nā pilikia hānai ʻē aʻe
• Nā ritme naʻau maʻamau (arrhythmia)

ʻAʻole loaʻa nā ʻōpio i nā ʻōuli a hiki i ka wā ʻōpio. I nā kaikamahine, hōʻailona nā CAH me:

• Nā wā menstrual maʻamau, a ʻaʻohe wā ʻē aʻe
• ʻO ka hele mua o ka lauoho pubic a me / a i ʻole ka lima
• ʻO ka lauoho nui ma ka maka a me ke kino
• Leo hohonu
• Pākuʻi hoʻonui ʻia

I nā keikikāne, loaʻa pū nā hōʻailona:

• Hoʻonui penis
• ʻŌpio ʻōpio (precocious puberty)

I nā kāne a me nā wahine makua, hoʻopili ʻia nā ʻōuli:

• Infertility (ka hiki ʻole ke hāpai a hāpai i kahi hoa hāpai)
• Huehue koʻikoʻi

He aha ka hana i ka wā o ka hoʻāʻo 17-OHP?

No kahi kānana hānau hou, e hoʻomaʻemaʻe kahi ʻoihana olakino i kou kuʻekuʻe wāwae o kāu pēpē me ka waiʻona a kuʻi i ka kuʻekuʻe wāwae me kahi nila liʻiliʻi. E hōʻiliʻili ka mea hāʻawi i kahi mau kulu o ke koko a kau i kahi kaula ma ka pūnaewele.

I ka wā o kahi hoʻokolohua koko no nā keiki makua a me nā mākua, e lawe kahi loea mālama ola i kahi laʻana koko mai kahi aa i loko o kou lima, e hoʻohana ana i kahi nila liʻiliʻi. Ma hope o ka hoʻokomo ʻia ʻana o ka nila, e hōʻiliʻili ʻia kahi koko liʻiliʻi i loko o kahi pahu hoʻāʻo a ipu paha. Hiki paha iā ʻoe ke ʻoni iki i ka wā e hele ai a kuʻi paha ka nila. Lōʻihi kēia ma mua o ʻelima mau minuke.

Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?

ʻAʻohe hoʻomākaukau kūikawā e pono ai no kahi hōʻike 17-OHP.

Aia kekahi mau pilikia i ka hoʻāʻo?

Heʻuʻuku ka makaʻu iā ʻoe a i ʻole kāu pēpē me kahi hōʻike 17-OHP. Loaʻa paha iā ʻoe ka ʻeha a ʻeha paha ma kahi o ka nila i hoʻokomo ʻia ai, akā ʻo ka hapa nui o nā ʻōuli e hele wikiwiki aku. ʻIke paha kāu pēpē i kahi ʻuʻuku ke kuʻi ʻia ka kuʻekuʻe wāwae, a kū paha kahi ʻeha liʻiliʻi ma ka pūnaewele. E hele wikiwiki kēia.

He aha ke ʻano o nā hopena?

Inā hōʻike nā hualoaʻa i nā pae kiʻekiʻe o 17-OHP, malia paha ʻo ʻoe a ʻo kāu keiki ʻo CAH. ʻO ka maʻamau, ʻo nā kiʻekiʻe kiʻekiʻe loa ke ʻano o kahi ʻano ʻoi aku ke koʻikoʻi, ʻoiai nā pae kiʻekiʻe kiʻekiʻe maʻa mau.

Inā mālama ʻia ʻoe a ʻo kāu keiki paha no CAH, manaʻo paha nā pae haʻahaʻa o 17-OHP e hana nei ka lāʻau. Hiki i ka mālama ʻana ke hoʻopili i nā lāʻau e pani i ka nalo ʻana o ka cortisol. I kekahi manawa hana ʻia ke ʻoki e hoʻololi i ka helehelena a me ka hana o nā genital.

Inā he mau nīnau kāu e pili ana i kāu hopena a i ʻole nā ​​hopena o kāu keiki, e kamaʻilio me kāu kauka olakino.

E aʻo hou aʻe e pili ana i nā hoʻokolohua hoʻokolohua, nā pae kuhikuhi, a me ka hoʻomaopopo ʻana i nā hopena.

Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i kahi hōʻike 17-OHP?

Inā ua ʻike ʻia ʻoe a ʻo kāu keiki paha me CAH, makemake paha ʻoe e kūkākūkā me ke kākāʻōlelo aʻoaʻo, he loea i hoʻomaʻamaʻa kūikawā ʻia i nā genetics. ʻO CAH kahi maʻi maʻi a kahi e pono ai i nā mākua ke hoʻololi i ka genetic e kumu iā CAH. Hiki i kahi makua ke lawe i ka ʻāpana, ʻo ia hoʻi he ʻāpana ko lākou akā ʻaʻohe o lākou mau hōʻailona o ka maʻi. Inā lawe nā mākua ʻelua, loaʻa i kēlā me kēia keiki he 25% manawa kūpono e loaʻa ai ke ʻano.

Nā kūmole

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ʻAʻole pono e hoʻohana i ka ʻike ma kēia pūnaewele i pani no ka mālama olakino ʻoihana a ʻōlelo aʻoaʻo paha. Kāhea aku i ka mea mālama ola inā he nīnau kāu e pili ana i kou olakino.