He aha ka chimerism, ʻano a pehea e ʻike ai

Anter

• Nā ʻano chimerism
• 1. Chimerism kūlohelohe
• 2. Chimerism hana
• 3. Microquimerismo
• 4. Chimerism māhoe
• Pehea e ʻike ai

ʻO Chimerism kahi ʻano o ka loli ʻano laha ʻole kahi e ʻike ʻia ai ke kū ʻana o ʻelua mau ʻaoʻao ʻokoʻa, a he kūlohelohe paha ia, i ka wā o ka hāpai ʻana, no ka laʻana, a i ʻole ma muli o ka hematopoietic stem cell transplantation, kahi o nā hunaola o nā cell donor transplanted lawe ʻia e ka mea e loaʻa ana, me ke ola pū ʻana o nā hunaola me nā ʻikepili pilikino like ʻole.

Ua manaʻo ʻia he chimerism ke hōʻoia ʻia ke alo o ʻelua a ʻoi paha mau heluna o nā ʻāpana genetically me nā kumu like ʻole, ʻokoʻa i nā mea e hana ʻia i loko o ka mosaicism, kahi o nā heluna o nā hunaola he ʻano like ʻole. E aʻo hou aʻe e pili ana i ka mosaicism.

Nā ʻano chimerism

ʻAʻole maʻamau ka Chimerism ma waena o nā poʻe a hiki ke ʻike maʻalahi ʻia i nā holoholona. Eia nō naʻe hiki i ka chimerism ma waena o ka poʻe, ʻo nā ʻano nui:

1. Chimerism kūlohelohe

Kū ka chimerism kūlohelohe ke hui ʻia he 2 a ʻoi paha embryos, e hana ana i hoʻokahi. No laila, hana ʻia ka pēpē e 2 a ʻoi mau mea ʻokoʻa ʻokoʻa.

2. Chimerism hana

Hana ʻia ia i ka manawa e loaʻa ai i ke kanaka ka transfusion o ke koko a i ʻole ka hoʻoneʻe iwi o ka iwi a i ʻole nā ​​hematopoietic i loaʻa i nā hunaola mai kahi kanaka ʻē aʻe, me nā huna mea hāʻawi e omo ana i ka meaola. Kūleʻa kēia kūlana i ka wā i hala, akā i kēia lā ma hope o nā transplants ukali ʻia ke kanaka a hana i kekahi mau ʻano lapaʻau e pale ai i ka omo mau ʻana o nā hunaola donor, me ka hōʻoia ʻana i ka ʻae maikaʻi ʻana o ke transplant e ke kino.

3. Microquimerismo

Kū kēia ʻano chimerism i ka wā o ka hāpai ʻana, kahi e omo ai ka wahine i kekahi mau hunaola mai ka pēpē a i ʻole ka omo omo i nā hunaola mai ka makuahine, a hopena i nā mea ʻelua.

4. Chimerism māhoe

Hana ʻia kēia ʻano chimerism i ka wā o ka hāpai ʻana o nā māhoe, make kekahi pēpē a lawe ʻē aʻe ka pēpē i kekahi o nā hunaola. No laila, he pēpē ponoʻī kā ka pēpē i hānau ʻia a me nā mea genetic o kona kaikaina.

Pehea e ʻike ai

Hiki ke ʻike ʻia ka chimerism ma o kekahi mau ʻano i hiki i ke kanaka ke hōʻike ma ke ʻano he wahi o ke kino me ka pigmentation ʻoi aku a liʻiliʻi paha, nā maka me nā kala like ʻole, ka hanana o nā maʻi autoimmune e pili ana i ka ʻili a i ʻole ka ʻōnaehana a me ka intersexual, kahi i loaʻa nā ʻano moekolohe ʻokoʻa a me nā lauana chromosomal, kahi mea paʻakikī e ʻike i ke kanaka no ke kāne a wahine paha.

Hoʻohui ʻia, ʻike ʻia ka chimerism ma o nā hoʻokolohua e loiloi i nā mea kūlohelohe, DNA, a me ke kū ʻana o ʻelua a ʻoi paha mau pālua o DNA i nā hunaola ʻulaʻula, no ka laʻana, hiki ke hōʻoia. Eia hou, i ka hihia o chimerism ma hope o ka hematopoietic stem cell transplantation, hiki ke ʻike ʻia kēia hoʻololi ʻana ma o ka hoʻokolohua genetic e loiloi i nā māka i ʻike ʻia ʻo STRs, i hiki ke hoʻokaʻawale i nā hunaola o ka mea loaʻa a me ka mea hāʻawi.