ʻO ka loiloi DNA Prenatal Cell-Free

Anter

• He aha kahi kānana DNA ʻole (prenatal cell-free DNA) (cfDNA) e nānā ʻia?
• Hoʻohana ʻia no ke aha?
• No ke aha wau e pono ai i kahi kānana CFDNA prenatal e nānā?
• He aha ka mea e hana ai i ka nānā ʻana i ka CFDNA prenatal?
• E pono paha wau e hana i kekahi mea e hoʻomākaukau ai no kēia hōʻike?
• Aia kekahi mau pilikia i ka hoʻāʻo?
• He aha ke ʻano o nā hopena?
• Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i kahi kānana CFDNA prenatal?
• Nā kūmole

He aha kahi kānana DNA ʻole (prenatal cell-free DNA) (cfDNA) e nānā ʻia?

ʻO ka Prenatal cell-free DNA (CFDNA) ka hōʻoia ʻana i ke koko no nā wahine hāpai. I ka wā o ka hāpai ʻana, ke hele nei kekahi o ka DNA hānau o kahi pēpē i ke kahe o ke koko o ka makuahine. Nānā kahi kānana CFDNA i kēia DNA e ʻike inā loaʻa pinepine ka pēpē Down i ka maʻi maʻi a i ʻole kekahi maʻi ʻē aʻe i hoʻokumu ʻia e kahi trisomy.

ʻO kahi trisomy kahi maʻi o nā chromosome. ʻO nā Chromosome nā ʻāpana o kāu mau pūnaewele i loaʻa i kāu mau ʻāpana. ʻO nā ʻāpana nā ʻāpana o ka DNA i hoʻoili ʻia mai kou makuahine a me kou makuakāne. Hāpai lākou i ka ʻike e hoʻoholo ai i kāu ʻano kū hoʻokahi, e like me ke kiʻekiʻe a me ke kala o ka maka.

• Loaʻa i nā kānaka he 46 chromosome, i mahele ʻia i 23 mau pālua, i kēlā me kēia cell.
• Inā loaʻa i kekahi o kēia mau pālua he kope keu o ka chromosome, ua kapa ʻia he trisomy. Hoʻokumu kahi trisomy i nā loli i ke ala e ulu ai ke kino a me ka lolo.
• I Down Syndrome, aia kekahi kope hou o ka chromosome 21. ʻIke ʻia kēia ma ke ʻano he trisomy 21. ʻO Down Syndrome ka maʻi chromosome maʻa mau i ʻAmelika Hui Pū ʻIa.
• ʻO nā maʻi trisomy ʻē aʻe e like me Edwards Syndrome (trisomy 18), kahi i loaʻa kahi kope keu o ka chromosome 18, a me ka Patau syndrome (trisomy 13), kahi i loaʻa kahi kope keu o ka chromosome 13. He laha kēia mau maʻi akā ʻoi aku ka koʻikoʻi ma mua o Down Syndrome. ʻO ka hapa nui o nā pēpē me trisomy 18 a i ʻole trisomy 13 e make i loko o ka makahiki mua o ke ola.

ʻAʻoheʻuʻuku ka makaʻu ʻana o kahi kānana CFDNA iā ʻoe a me kāu pēpē, akā ʻaʻole hiki iā ia ke haʻi iā ʻoe inā he maʻi chromosome kāu pēpē. Pono kāu mea mālama ola e kauoha i nā hoʻokolohua ʻē aʻe e hōʻoia a hōʻalo paha i kahi kuhi.

Nā inoa ʻē aʻe: DNA fetal-cell fetal, cffDNA, hoʻokolohua prenatal ʻole invasive, NIPT

Hoʻohana ʻia no ke aha?

Hoʻohana pinepine ʻia kahi kānana CFDNA e hōʻike inā loaʻa ka nui o ka makaʻu o kāu pēpē i hānau ʻole ʻia no kekahi o nā maʻi chromosome aʻe:

• Down syndrome (trisomy 21)
• Edwards maʻi pale (trisomy 18)
• Patau syndrome (trisomy 13)

Hiki ke hoʻohana ʻia ke kānana ʻana i:

• E hoʻoholo i ka wahine kāne a wahine paha. Hiki ke hana ʻia inā hōʻike kahi ultrasound i ka maopopo ʻole o nā genital o kahi pēpē he kāne a wahine paha. Hiki ke kumu ʻia kēia e kahi maʻi o nā chromosome wahine.
• Hōʻoia Rh ʻano koko. He protein ʻo Rh i loaʻa i nā hunaola ʻulaʻula. Inā loaʻa iā ʻoe ka protein, manaʻo ʻia ʻoe ʻo Rh maikaʻi. Inā ʻaʻole ʻoe, Rh maikaʻi ʻole ʻoe. Inā maikaʻi ʻole ʻoe a Rh a maikaʻi ʻole kāu pēpē i hānau ʻole ʻia Rh, hiki i kou ʻōnaehana pale kino ke hoʻouka i nā hunaola koko o kāu pēpē. Inā ʻike ʻoe he Rh maikaʻi ʻole ʻoe i ka wā mua o ka hāpai ʻana, hiki iā ʻoe ke lawe i nā lāʻau e pale ai i kāu pēpē mai nā pilikia weliweli.

Hiki ke hana ʻia kahi kānana CFDNA i ka wiki 10 o ka hāpai ʻana.

No ke aha wau e pono ai i kahi kānana CFDNA prenatal e nānā?

Hoʻomaopopo ka poʻe lawelawe olakino he nui i kēia loiloi i nā wahine hāpai i ʻoi aku ka nui o ka makaʻu i ka loaʻa ʻana o kahi pēpē me ka maʻi chromosome. Hiki paha iā ʻoe ke makaʻu kiʻekiʻe aʻe inā:

• He 35 a ʻoi kou mau makahiki. ʻO ka makahiki o ka makuahine ka mea nui pilikia no ka loaʻa ʻana o kahi pēpē me Down Syndrome a i ʻole nā ​​maʻi trisomy ʻē aʻe. Hoʻonui ka makaʻi i ka nui ʻana o ka wahine.
• Ua loaʻa iā ʻoe kahi pēpē hou aʻe me ka maʻi chromosome.
• ʻAʻole i nānā maʻamau kāu ultrasound fetal.
• ʻAʻole maʻamau nā hopena hōʻike prenatal ʻē aʻe.

Paipai kekahi kahu mālama ola i ka nānā ʻana i nā wahine hāpai āpau. ʻO kēia no ka mea ʻaneʻane ʻaʻohe makaʻu o ka kānana a he kiʻekiʻe kiʻekiʻe o ka pololei ke hoʻohālikelike ʻia me nā hoʻokolohua loiloi prenatal ʻē aʻe.

Pono ʻoe a me kāu kahu mālama ola e kūkākūkā inā kūpono kahi kānana CFDNA nāu.

He aha ka mea e hana ai i ka nānā ʻana i ka CFDNA prenatal?

E lawe kahi ʻoihana mālama ola i kahi laʻana koko mai kahi aa i kou lima, e hoʻohana ana i kahi nila kuʻikuʻi. Ma hope o ka hoʻokomo ʻia ʻana o ka nila, e hōʻiliʻili ʻia kahi koko liʻiliʻi i loko o kahi pahu hoʻāʻo a ipu paha. Hiki paha iā ʻoe ke ʻoni iki i ka wā e hele ai a kuʻi paha ka nila. Lōʻihi kēia ma mua o ʻelima mau minuke.

E pono paha wau e hana i kekahi mea e hoʻomākaukau ai no kēia hōʻike?

E makemake paha ʻoe e ʻōlelo i kahi kākāʻōlelo genetic ma mua o ka hoʻāʻo ʻana. He loea aʻoaʻo aʻo loea kūikawā i ka genetics a me ka hoʻāʻo genetic. Hiki iā ia ke wehewehe i nā hopena i hiki a me ke ʻano o lākou iā ʻoe a me kāu pēpē.

Aia kekahi mau pilikia i ka hoʻāʻo?

ʻAʻohe mea makaʻu i kāu pēpē i hānau ʻole a liʻiliʻi iki iā ʻoe. Loaʻa paha iā ʻoe ka ʻeha a ʻeha paha ma kahi o ka nila i hoʻokomo ʻia ai, akā ʻo ka hapa nui o nā ʻōuli e hele wikiwiki aku.

He aha ke ʻano o nā hopena?

Inā maikaʻi ʻole kāu hopena, ʻaʻole paha paha loaʻa kāu pēpē i Down Syndrome a i ʻole kahi maʻi trisomy ʻē aʻe. Inā maikaʻi kāu mau hopena, ʻo ia hoʻi ka hoʻonui ʻia o ka makaʻu i loaʻa i kāu pēpē kekahi o kēia mau maʻi. Akā ʻaʻole hiki ke haʻi pololei iā ʻoe inā pili kāu pēpē. No kahi hōʻoia hou aku e pono ai ʻoe i nā hoʻokolohua ʻē aʻe, e like me ka amniocentesis a me ka chorionic villus sampling (CVS). He palekana loa kēia mau hoʻāʻo, akā loaʻa iā lākou i kahi makaʻu iki o ka hānau ʻana.

Inā he mau nīnau kāu e pili ana i kāu mau hopena, e kamaʻilio me kāu kauka olakino a / a i ʻole he kākāʻolelo aʻoaʻo.

E aʻo hou aʻe e pili ana i nā hoʻokolohua hoʻokolohua, nā pae kuhikuhi, a me ka hoʻomaopopo ʻana i nā hopena.

Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i kahi kānana CFDNA prenatal?

ʻAʻole pololei nā kānana CFDNA i nā wahine hāpai i nā keiki ʻoi aku ma mua o hoʻokahi (māhoe, ʻekolu a ʻoi aku paha).

Nā kūmole

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ʻAʻole pono e hoʻohana i ka ʻike ma kēia pūnaewele i pani no ka mālama olakino ʻoihana a ʻōlelo aʻoaʻo paha. Kāhea aku i ka mea mālama ola inā he nīnau kāu e pili ana i kou olakino.