He hoʻoilina ʻo Psoriasis?

Anter

• Aia kekahi loulou ma waena o nā genetics a me psoriasis?
• He aha nā mea kōkua ʻē aʻe i psoriasis?
• Hiki ke hoʻohana i ka genotherapy e mālama ai iā psoriasis?
• Pehea e mālama maʻamau ai ʻo psoriasis?
• Lawe aku

He aha ka psoriasis a pehea ʻoe e loaʻa ai?

ʻO ka Psoriasis kahi ʻano ʻili e hōʻike ʻia e nā unahi unahi, ka mumū, a me ka ʻulaʻula. Hana ʻia ia ma ke poʻo, nā kuli, kuʻekuʻe lima, a me nā wāwae.

Wahi a kekahi noiʻi, ma kahi o 7.4 miliona mau kānaka ma ʻAmelika Hui Pū ʻIa e noho nei me ka psoriasis ma 2013.

He maʻi maʻi autoimmune ʻo Psoriasis. ʻIke kuhihewa nā hunaola ʻino i loko o kou koko i nā huna ʻili i hana hou ʻia ma ke ʻano he poʻe kūwaho haole a hoʻouka iā lākou. Hiki i kēia ke kumu i ka hana nui ʻana o nā hunaola hou ma lalo o ka ʻili o kou ʻili.

Hele kēia mau hunaola hou i ka ʻili a koi aku i nā huna ʻili e kū nei. ʻO ia ke kumu o nā unahi, ka ʻili, a me ka mumū o ka psoriasis.

ʻAneʻane hana nui nā Genetics. E heluhelu e aʻo hou aʻe e pili ana i ka hana a nā genetics i ka hoʻomohala ʻana i ka psoriasis.

Aia kekahi loulou ma waena o nā genetics a me psoriasis?

Hōʻike pinepine ʻia ʻo Psoriasis ma waena o nā makahiki 15 a 35, e like me ka National Psoriasis Foundation (NPF). Eia nō naʻe, hiki i kēlā me kēia makahiki. ʻO kahi laʻana, ma kahi o 20,000 mau keiki ma lalo o 10 mau makahiki e ʻike ʻia me ka psoriasis i kēlā me kēia makahiki.

Hiki ke hana ʻia ʻo Psoriasis i ka poʻe me ka ʻole o ka moʻolelo ʻohana o ka maʻi. ʻO ka loaʻa ʻana o kahi lālā o ka ʻohana me ka maʻi e hoʻonui i kou makaʻu.

• Inā he psoriasis kekahi o kou mau mākua, loaʻa iā ʻoe ma kahi o 10 pakeneka ka loaʻa ʻana o ia.
• Inā loaʻa ka maʻi o kāu mau mākua ʻelua, 50 pākēneka kou makaʻu.
• Ma kahi o ka hapakolu o ka poʻe i ʻike ʻia me ka psoriasis e pili pū me ka psoriasis.

Hoʻomaka ka ʻepekema e hana nei i nā kumu genetics o ka psoriasis ma ke kuhi ʻana he hopena ka hopena mai kahi pilikia me ka ʻōnaehana pale. ma ka ʻili psoriatic e hōʻike nei he nui ka nui o nā hunaola pale e hana i nā mole mole i ʻike ʻia ʻo cytokines.

Aia i loko o ka ʻili Psoriatic ka hoʻololi ʻana o ka ʻenela i kapa ʻia he alleles.

ʻO ka noiʻi mua ʻana i nā makahiki 1980 i alakaʻi ʻia ai i ka manaʻo he kuleana ʻokoʻa kahi alele kikoʻī ke kuleana no ka hoʻoili ʻana i ka maʻi ma o nā ʻohana.

ma hope ua ʻike ʻia ka hiki ʻana mai o kēia alele, HLA-Cw6, ʻaʻole lawa e hoʻomohala i kahi kanaka i ka maʻi. Hōʻike hou aʻe e pono ana ka noiʻi hou e hoʻomaopopo pono i ka pilina ma waena HLA-Cw6 a me ka psoriasis.

ʻO ka hoʻohana ʻana i nā ʻenehana hou aʻe i alakaʻi ʻia i ka ʻike ʻana ma kahi o 25 mau ʻāpana ʻokoʻa i nā mea kūpuna kanaka (ka genome) i pili pū ʻia me ka psoriasis.

A ʻo kahi hopena, hiki i nā ʻike kūpuna ke hāʻawi iā mākou i kahi hōʻailona o ka makaʻu o ke kanaka i ka hoʻomohala ʻana i ka psoriasis. ʻO ka loulou ma waena o nā gen e pili ana i ka psoriasis a me ke ʻano ponoʻī ʻaʻole maopopo pono.

Hoʻopili ka Psirus i ka pilina ma waena o kāu ʻōnaehana pale a me kou ʻili. ʻO ia ka ʻōlelo paʻakikī e ʻike he aha ke kumu a he aha ka hopena.

ʻO nā mea hou i loaʻa i ka noiʻi kūpuna i hāʻawi mai i nā ʻike nui, akā ʻaʻole naʻe mākou e maopopo pono i ke kumu o ka pā mai ʻana o ka maʻi psoriasis. ʻO ke ala kikoʻī e hāʻawi ʻia ai ʻo psoriasis mai ka makua a ke keiki ʻaʻole maopopo loa.

He aha nā mea kōkua ʻē aʻe i psoriasis?

ʻO ka hapa nui o ka poʻe me psoriasis he mau maʻi kūlohelohe a i ʻole ke ahi i ukali ʻia e nā manawa o ke kala. Ma kahi o 30 pākēneka o ka poʻe me ka psoriasis ʻike pū i ka mumū o nā hono e like me ka maʻi ʻōpū. Kapa ʻia kēia ʻo psoriatic arthritis.

ʻO nā kumu kaiapuni e hoʻonāuki i ka hoʻomaka ʻana o ka psoriasis a i ʻole ke ahi i luna:

• hoʻoluhi
• ke anuanu a me ke anuanu
• Maʻi HIV
• nā lāʻau e like me ka lithium, beta-blockers, a me nā antimalarials
• ka huki ʻana i nā corticosteroids

ʻO ka hōʻeha a hōʻeha paha i kahi ʻāpana o kou ʻili i kekahi manawa e lilo i pūnaewele o kahi flare psoriasis. Hiki paha i ka maʻi ke hoʻonāukiuki. Hoʻomaopopo ka NPF i ka maʻi, ʻoiai ʻo ka ʻāʻī strep i ka poʻe ʻōpio, i hōʻike ʻia ma ke ʻano he kumu no ka hoʻomaka ʻana o ka maʻi psoriasis.

ʻOi aku paha kekahi mau maʻi i ka poʻe me psoriasis ma mua o ka heluna lehulehu. I hoʻokahi noiʻi o nā wahine me ka psoriasis, ma kahi o 10 pākēneka o nā poʻe i komo pū kekahi i hoʻomohala i kahi maʻi ʻōpala e like me ka maʻi o Crohn a i ʻole colitis ulcerative.

ʻO ka poʻe me psoriasis i hoʻonui ʻia ka hanana o:

• lymphoma
• maʻi maʻi puʻuwai
• momona
• ʻano 2 diabetes
• maʻi maʻi metabolic
• kaumaha a me ka pepehi kanaka
• inu lama
• puhipaka

Hiki ke hoʻohana i ka genotherapy e mālama ai iā psoriasis?

ʻAʻole i loaʻa i kēia manawa ka gen therapy ma ke ʻano he lapaʻau, akā aia ka hoʻonui ʻia o ka noiʻi ʻana i nā kumu kūpuna o ka psoriasis. I loko o kekahi o nā mea i loaʻa e hoʻohiki nui ʻia, ua loaʻa i nā mea noiʻi kahi hoʻololi laha ʻole e pili ana i ka psoriasis.

ʻIke ʻia ka hoʻololi ʻana o nā gen Kāleka14. Ke hōʻike ʻia i kahi mea kaiapuni, e like me ka maʻi, hana kēia mutation i ka plake psoriasis. ʻO ka plaque psoriasis ka ʻano maʻamau o ka maʻi. Ua kōkua kēia ʻike i ka hoʻokumu ʻana i ka Kāleka14 hoʻololi i psoriasis.

Ua loaʻa kēia mau mea noiʻi like i ka Kāleka14 i loko o nā ʻohana nui ʻelua i loaʻa i nā lālā ʻohana he nui me ka plake psoriasis a me ka psoriatic arthritis.

ʻO kēia kekahi o nā ʻike hou loa e paʻa ka hoʻohiki i hiki i kekahi ʻano o ka gen therapy ke hiki i kekahi lā ke kōkua i ka poʻe e noho ana me ka psoriasis a i ʻole ka psoriatic arthritis.

Pehea e mālama maʻamau ai ʻo psoriasis?

No nā hihia mehana a kaulike hoʻi, paipai nā dermatologists i nā mālama kumuhana e like me nā kalima a me nā hamo. Hiki i kēia mau mea ke:

• anthralin
• kākahu lānahu
• waikawa salicylic
• tazarotene
• Corticosteroids
• wikamina D

Inā loaʻa iā ʻoe kahi hihia ʻoi aku ka koʻikoʻi o ka psoriasis, hiki i kāu kauka ke kuhikuhi i ka phototherapy a me nā lāʻau ʻōnaehana ʻōnaehana a i ʻole biologic ʻoi aku ka nui, i lawe waha ʻia a i ʻole ka ʻume.

Lawe aku

Ua hoʻokumu nā kānaka noiʻi i kahi loulou ma waena o psoriasis a me nā genetics. ʻO ka loaʻa ʻana o ka mōʻaukala ʻohana o kēia ʻano e hoʻonui ai i kou makaʻā. Pono hou kahi noiʻi e hoʻomaopopo piha i ka hoʻoilina o psoriasis.