Mea Kākau: Gregory Harris
Lā O Ka Hana: 11 Apelila 2021
HōʻAno Hou I Ka Lā: 27 Ianuali 2025
Anonim
BRAF: from gene to cancer therapy
Wikiō: BRAF: from gene to cancer therapy

Anter

He aha ka hoʻokolohua kūlohelohe BRAF?

Ke nānā nei kahi hōʻike hoʻāʻo BRAF no kahi loli, i ʻike ʻia ma ke ʻano he mutation, i kahi moʻokūʻauhau i kapa ʻia ʻo BRAF. ʻO nā Genes nā ʻāpana maʻamau o ka hoʻoilina i hoʻoili ʻia mai kou makuahine a me kou makuakāne.

Hana ka ʻāpana BRAF i kahi protein i kōkua i ka mālama ʻana i ka ulu ʻana o ka cell. ʻIke ʻia he oncogene. Hana kahi oncogene e like me ka hehi wāwae kaʻa ma ke kaʻa. ʻO ka maʻamau, huli kahi oncogene i ka ulu ʻana o ka pūnaewele e like me ka mea e pono ai. Akā inā loaʻa iā ʻoe kahi hoʻololi BRAF, like ia me ka paʻa o ke kūpikipiki i lalo, a ʻaʻole hiki i ka ʻāpana ke hoʻokū i nā pūnaewele mai ka ulu ʻana. Hiki i ke ulu ʻana o ke koleke ke alakaʻi ʻole ʻia i ka maʻi ʻaʻai.

Hiki ke hoʻoilina ʻia kahi hoʻololi BRAF mai kou mau mākua a i ʻole loaʻa ma hope i ke ola. Hoʻokumu pinepine ʻia nā loli ma hope o ke ola e ke kaiapuni a i ʻole mai kahi kuhihewa i hiki i kou kino i ka wā o ka mahele o ka cell. He kakaikahi loa ka hoʻoilina BRAF hoʻoilina, akā hiki iā lākou ke hoʻopilikia i nā pilikia olakino koʻikoʻi.

Loaʻa ʻia (ʻike ʻia ʻo somatic) ʻoi aku ka nui o nā hoʻololi BRAF. Ua loaʻa kēia mau mutation ma kahi o ka hapalua o nā hihia āpau o melanoma, ke ʻano koʻikoʻi o ka maʻi ʻaʻai ʻili. ʻIke pinepine ʻia nā hoʻololi BRAF i nā maʻi ʻē aʻe a me nā ʻano like ʻole o ka maʻi ʻaʻai, e like me nā maʻi ʻaʻai o ke kolona, ​​thyroid, a me nā ovaries. ʻOi aku ka koʻikoʻi o nā ʻōpala me kahi hoʻololi BRAF ma mua o nā mea me ka ʻole o ka hoʻololi.


Nā inoa ʻē aʻe: BRAF gene mutation analysis, Melanoma, BRAF V600 mutation, cobas

No ke aha ia e hoʻohana ai?

Hoʻohana pinepine ʻia ka hoʻāʻo e nānā no ka hoʻololi BRAF i nā mea maʻi me ka melanoma a i ʻole nā ​​maʻi ʻē aʻe e pili ana i ka BRAF. ʻO kekahi o nā lāʻau lapaʻau maʻi ʻaʻai e maikaʻi loa i ka poʻe i loaʻa kahi mutation BRAF. ʻAʻole maikaʻi nā lāʻau like a weliweli i kekahi manawa i ka poʻe i loaʻa ʻole ka hoʻololi.

Hoʻohana ʻia paha ka hoʻāʻo BRAF e ʻike inā makaʻu ʻoe i ka maʻi ʻaʻai e pili ana i ka mōʻaukala ʻohana a me / a i ʻole kāu mōʻaukala ponoʻī.

No ke aha wau e pono ai i kahi hoʻokolohua kūlohelohe BRAF?

Pono paha ʻoe e hōʻoia i ka BRAF inā ua hōʻoia ʻia ʻoe me ka melanoma a i ʻole kekahi ʻano maʻi ʻaʻai. ʻO ka ʻike inā he mutation kāu e hiki ke kōkua i kāu mea hāʻawi e kuhikuhi i ka lāʻau kūpono.

Pono paha ʻoe i kēia hōʻoia e ʻike inā ʻoe i ka makaʻu kiʻekiʻe no ka loaʻa ʻana i ka maʻi ʻaʻai. ʻO nā kumu pilikia e pili ana i ka moʻolelo ʻohana o ka maʻi ʻaʻai a me / a i ʻole ke loaʻa ʻana i ka maʻi ʻaʻai i ka wā ʻōpio. Aia ka makahiki kikoʻī i ke ʻano o ka maʻi ʻaʻai.


He aha ka hana i ka wā o ka hoʻāʻo genetika BRAF?

Hana ʻia ka hapa nui o nā hoʻokolohua BRAF i kahi hana i kapa ʻia he biopsy tumo. I loko o kahi biopsy, e lawe kahi mea mālama ola i kahi ʻāpana liʻiliʻi o ke kino ma ka ʻoki ʻana a ʻoki ʻana i ka ʻili o kahi tumo. Inā pono kāu mea lawelawe e hoʻāʻo i nāʻiʻo tumora mai loko aʻe o kou kino, e hoʻohana paha ʻo ia i kahi nila kuikawa e huki ai i ka hāpana.

Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?

ʻAʻole pono ʻoe i kahi hoʻomākaukau kūikawā no ka hoʻāʻo BRAF.

Aia kekahi mau pilikia i ka hoʻāʻo?

Loaʻa paha iā ʻoe kahi palapū a kōkō liʻiliʻi paha ma ka pūnaewele biopsy. Hiki paha iā ʻoe ke hōʻoluʻolu iki ma ka pūnaewele no hoʻokahi a ʻelua paha lā.

He aha ke ʻano o nā hopena?

Inā loaʻa ʻoe i kahi melanoma a i ʻole kekahi ʻano maʻi ʻaʻai, a hōʻike nā hopena iā ʻoe he mutation BRAF, hiki i kāu mea hāʻawi ke kuhikuhi i nā lāʻau i hoʻolālā ʻia e māka i ka hoʻololi. Hiki ke ʻoi aku ka maikaʻi o kēia mau lāʻau ma mua o nā ʻano lāʻau ʻē aʻe.

Inā loaʻa ʻoe i ka melanoma a i ʻole ke ʻano maʻi ʻaʻai, a hōʻike nā hopena iā ʻoe mai hana loaʻa kahi hoʻololi, e kauoha ana kāu mea hāʻawi i nā ʻano lāʻau like ʻole e mālama i kāu maʻi ʻaʻai.


Inā ʻaʻole ʻoe i kuhi ʻia me ka maʻi ʻaʻai a hōʻike kāu mau hopena loaʻa iā ʻoe kahi hoʻololi BRAF genetical, ia ʻaʻole ʻO ka manaʻo he maʻi maʻi kou, akā ʻoi aku kou kiʻekiʻe i ka maʻi ʻaʻai. Akā ʻo ka loiloi pinepine ʻana o ka maʻi ʻaʻai, e like me ka hoʻokolohua ʻili, hiki ke hōʻemi i kou makaʻi. I ka wā o kahi hoʻokolohua ʻili, e nānā pono kahi mea mālama ola ma luna o ka ʻili ma kou kino holoʻokoʻa e nānā no nā mole a me nā ulu kānalua ʻē aʻe.

E kamaʻilio i kāu mea hoʻolako e pili ana i nā kaʻina ʻē aʻe i hiki iā ʻoe ke lawe e hōʻemi i kāu makaʻu.

E aʻo hou aʻe e pili ana i nā hoʻokolohua hoʻokolohua, nā pae kuhikuhi, a me ka hoʻomaopopo ʻana i nā hopena.

Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i kahi hōʻike BRAF?

Lohe paha ʻoe i kāu mea hāʻawi e kamaʻilio e pili ana i kahi mutation V600E. Aia nā ʻano like ʻole o ka hoʻololi BRAF. ʻO V600E ka ʻano maʻamau o ka hoʻololi BRAF.

Nā kūmole

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ʻAʻole pono e hoʻohana i ka ʻike ma kēia pūnaewele i pani no ka mālama olakino ʻoihana a ʻōlelo aʻoaʻo paha. Kāhea aku i ka mea mālama ola inā he nīnau kāu e pili ana i kou olakino.

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