Mea Kākau: Virginia Floyd
Lā O Ka Hana: 5 Aukake 2021
HōʻAno Hou I Ka Lā: 21 Ianuali 2025
Anonim
DOVATO® (dolutegravir/lamivudine) Mechanism of Action for HIV
Wikiō: DOVATO® (dolutegravir/lamivudine) Mechanism of Action for HIV

Anter

E haʻi aku i kāu kauka inā loaʻa a manaʻo paha ʻoe he maʻi maʻi hepatitis B (HBV; kahi maʻi akepaʻa mau). E hoʻāʻo paha kāu kauka iā ʻoe e ʻike inā loaʻa iā ʻoe ka HBV ma mua o kou hoʻomaka ʻana i kāu lāʻau me dolutegravir a me lamivudine. Inā loaʻa iā ʻoe ka HBV a lawe ʻoe i ka dolutegravir a me ka lamivudine, e ʻinoʻino paha kou ʻano ke kū ʻoe i ka lawe ʻana i ka dolutegravir a me ka lamivudine. E nānā ana kāu kauka iā ʻoe a kauoha pinepine i nā hoʻokolohua lab no nā mahina he nui ma hope o kou hoʻōki ʻana i ka lawe ʻana i ka dolutegravir a me ka lamivudine e ʻike inā ua ʻino kāu HBV.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua e nānā i ka pane o kou kino i ka dolutegravir a me ka lamivudine.

E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i ka dolutegravir a me ka lamivudine.

Hoʻohana wale ʻia ka hui ʻana o dolutegravir a me lamivudine e mālama ai i ka maʻi HIV (HIV) kanaka i kekahi poʻe i mālama ʻole ʻia me nā lāʻau HIV ma mua. Aia ʻo Lamivudine i loko o ka papa o nā lāʻau i kapa ʻia he nucleoside analogue hoʻohuli transcriptase (NRTI) a me dolutegravir i loko o ka papa o nā lāʻau i kapa ʻia integrase strand transfer inhibitors (INSTI). Hana lākou ma ka hoʻemi ʻana i ka nui o ka maʻi HIV i kou koko a hoʻonui i ka helu o nā hunaola pale e kōkua i ke kaua ʻana i nā maʻi i kou kino. ʻOiai ʻaʻole e hoʻōla ka dolutegravir a me ka lamivudine i ka maʻi HIV, hiki i kēia mau lāʻau ke hoʻoliʻiliʻi i kou manawa o ka hoʻomohala ʻia ʻana o ka maʻi immunodeficiency (AIDS) a me nā maʻi e pili ana i ka maʻi HIV e like me nā maʻi ʻino a i ʻole ke kanesa. ʻO ka lawe ʻana i kēia mau lāʻau a me ka hoʻomaʻamaʻa ʻana i ka moekolohe ʻoi aku ka maikaʻi a me ka hoʻololi ʻana i nā ʻano nohona ʻē aʻe e hōʻemi paha i ka makaʻi ʻana o ka loaʻa ʻana a i ʻole ka lawe ʻana i ka maʻi HIV i kekahi poʻe ʻē aʻe.


ʻO ka hui pū ʻana o dolutegravir a me lamivudine e hele mai ana ma ke ʻano he papa e lawe ʻia e ka waha. Lawe pinepine ʻia me ka ʻai ʻole a ʻai ʻole hoʻokahi manawa i ka lā. E lawe i ka dolutegravir a me ka lamivudine ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka dolutegravir a me ka lamivudine e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea, a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Kōkua ʻo Dolutegravir a me lamivudine e kaohi i ka maʻi HIV akā ʻaʻole e hoʻōla iā ia. E hoʻomau i ka lawe ʻana i ka dolutegravir a me ka lamivudine ʻoiai inā maikaʻi ʻoe. Mai hōʻoki i ka lawe ʻana i ka dolutegravir, a me ka lamivudine me ke kamaʻilio ʻole ʻana me kāu kauka. Inā kū ʻoe i ka lawe ʻana i ka dolutegravir a me ka lamivudine a i ʻole ke nalo ʻana i nā lāʻau, e ʻoi aku ka paʻakikī o kou ʻano e mālama. Ke hoʻomaka ka haʻahaʻa o kāu lako o dolutegravir a me lamivudine, e kiʻi hou mai kāu kauka a kauka paha.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.


Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka dolutegravir a me ka lamivudine,

  • e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka dolutegravir, lamivudine, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea i loko o ka dolutegravir a me nā papa lamivudine. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • E haʻi i kāu kauka inā lawe ʻoe i dofetilide (Tikosyn). E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka dolutegravir a me ka lamivudine inā ʻoe e lawe i kēia lāʻau.
  • e haʻi i kāu kauka a me ka mea lapaʻau i nā lāʻau lapaʻau a me nā lāʻau ʻole ʻē aʻe, nā wikamina, nā mea hoʻopihaʻai pono āu e lawe nei a hoʻolālā paha e lawe. E haʻi pono i kekahi o kēia mau mea: carbamazepine (Carbatrol, Equetro, Tegretol, a me nā mea ʻē aʻe), dalfampridine (Ampyra), metformin (Glumetza, Glucophage, Riomet, i Invokamet, i Janumet, a me nā mea ʻē aʻe), oxcarbazepine (Oxtellar XR, Trileptal), phenobarbital, phenytoin (Dilantin, Phenytek), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), a me sorbitol a i ʻole nā ​​lāʻau i loaʻa ka sorbitol. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • inā ʻoe e lawe i nā antacids a i ʻole nā ​​laxatives i loaʻa i loko o ka aluminika a me ka magnesium; sucralfate (Carafate); aiʻole nā ​​lāʻau lapaʻau buffered e like me aspirin buffered, lawe iā lākou ma kahi o 2 mau hola ma hope a i ʻole 6 mau hola ma mua o kou lawe ʻana i ka dolutegravir a me ka lamivudine.
  • inā ʻoe e lawe i nā mea hoʻohui hao a i ʻole calcium, a i ʻole multivitamins i piha i ka hao a i ka calcium, lawe iā lākou i ka manawa like e lawe ai ʻoe i ka dolutegravir a me ka lamivudine me ka meaʻai, a i ʻole lawe iā lākou ma kahi o 2 mau hola ma hope a i ʻole 6 mau hola ma mua o kou lawe ʻana i ka dolutegravir a me ka lamivudine .
  • e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
  • e haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe i ka maʻi hepitis C hepatitis (HCV; kahi maʻi ate e hoʻomau ʻia ana) a i ʻole nā ​​maʻi ate, a i ʻole nā ​​maʻi puʻupaʻa.
  • e haʻi i kāu kauka inā hāpai ʻoe, a i ʻole hoʻolālā e hāpai. Pono ʻoe e lawe i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau. ʻAʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i ka dolutegravir a me ka lamivudine. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Inā hāpai ʻoe i ka lawe ʻana i ka dolutegravir a me ka lamivudine, e kāhea koke i kāu kauka.
  • e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū.ʻAʻole pono ʻoe e hānai i ka hānai inā loaʻa ʻoe i ka maʻi HIV a inā ʻoe e lawe i ka dolutegravir a me ka lamivudine.
  • pono ʻoe e ʻike ʻoiai ʻoe e lawe nei i nā lāʻau e mālama ai i ka maʻi HIV, e ikaika paha kāu ʻōnaehana pale a hoʻomaka e hakakā i nā maʻi ʻē aʻe i hala i kou kino a i ʻole e hana i nā hanana ʻē aʻe. Hiki iā ʻoe ke hoʻomohala i nā ʻōuli o kēlā mau maʻi a i ʻole nā ​​kūlana. Inā loaʻa iā ʻoe nā hōʻailona hou a pōʻino paha i ka wā o kāu mālama ʻana me dolutegravir a me lamivudine, e haʻi pono i kāu kauka.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Dolutegravir a me lamivudine i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • ʻeha poʻo
  • nausea
  • pāhoehoe
  • ʻenekini
  • paʻakikī e hiamoe a hiamoe paha
  • luhi
  • nāwaliwali o nā mākala

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, a i ʻole nā ​​mea i helu ʻia i ka ʻĀLU MAKAHIKI kūikawā, e kāhea koke i kāu kauka:

  • melemele o nā maka a i ʻole ʻili, ʻeha o ka ʻōpū, nā noho ʻōniʻoniʻo, nā mimi ʻeleʻele, nausea, luaʻi, nalo ʻole o ka makemake
  • ka luhi nui a i ʻole nāwaliwali, ʻehaʻeha, paʻakikī i ka hanu ʻana, ʻeha o ka ʻōpū, nausea, ka luaʻi, anuanu keu hoʻi i loko o kou mau lima a me kou mau wāwae, ʻeha, wikiwiki a kūʻē ʻole paha ka puʻuwai.
  • hū (me ka ʻole o nā ʻōuli ʻē aʻe)

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e hoʻōki i ka lawe ʻana i ka dolutegravir a me ka lamivudine a kāhea koke aku i kāu kauka a i ʻole e kiʻi i nā lāʻau lapaʻau pilikia.

  • hives, pehu o ka maka, puʻu, alelo, a mau lehelehe, ʻulaʻula a pehu paha nā maka, paʻakikī i ka ale ʻana a me ka hanu ʻana
  • hū me kekahi o nā hōʻailona aʻe; kuni; nā hōʻailona like flu-like; luhi loa; ʻeha a ʻeha pū paha. ʻili a ihi paha i ka ʻili; ʻeha a palapū paha i ka waha; a ʻulaʻula paha, ʻili, maka wai hoʻi,

Hoʻokumu paha ʻo Dolutegravir a me lamivudine i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Ma mua o ka hoʻāʻo ʻana o kahi keʻena hoʻokolohua, e haʻi i kāu kauka a me nā limahana o ke keʻena hoʻokolohua ke lawe nei ʻoe i ka dolutegravir a me ka lamivudine.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

E mālama i kahi lako o dolutegravir a me lamivudine ma ka lima. Mai kali a hiki i ka pau ʻana o kāu lāʻau e hoʻopiha hou i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • ʻO Dovato® (ma ke ʻano he huahana hoʻohui me Dolutegravir, Lamivudine)
  • dolutegravir a me 3TC
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