Larotrectinib

Anter

• Ma mua o ka lawe ʻana i larotrectinib,
• Hana ʻo Larotrectinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole kēlā mau mea i ka ʻĀKAHI MAKAHIKI ʻāpana, e kelepona koke i kāu kauka a i ʻole e kiʻi i nā lāʻau lapaʻau pilikia

Hoʻohana ʻia ʻo Larotrectinib e mālama i kekahi ʻano tumors paʻa i ka poʻe mākua a me nā keiki he 1 a ʻoi mau makahiki a ʻoi paha i pāhola aʻe i nā ʻāpana ʻē aʻe o ke kino a i ʻole hiki ʻole ke mālama kūleʻa ʻia me ke ʻoki kino. Hoʻohana wale ʻia kēia lāʻau lapaʻau inā ʻaʻohe loaʻa nā lāʻau lapaʻau ʻē aʻe a ua ʻoi aku ka ʻino o nā tumors ma hope o ka loaʻa ʻana o nā lāʻau ʻē aʻe. Aia ʻo Larotrectinib i kahi papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o ka protein pono ʻole e haʻi i nā hunaola maʻi ʻaʻai e hoʻonui. Hiki i kēia ke kōkua i ka lohi o ka ulu ʻana o nā tumors.

Hele mai ʻo Larotrectinib ma ke ʻano he capsule a ma ke ʻano he solution (wai) e lawe ʻia e ka waha. Lawe pinepine ʻia me a me ka ʻole o ka meaʻai i ʻelua mau lā. Lawe i ka larotrectinib ma nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka larotrectinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā capsule a pau i ka wai; mai nahu a paopao iā lākou.

E hoʻohana i kahi syringe waha (ana hāmeʻa) e ana pololei a lawe i kāu mahele lāʻau o larotrectinib solution. E noi i kāu kauka lāʻau no kahi syringe waha inā ʻaʻole i hoʻokomo ʻia kekahi me kāu lāʻau. Mai hoʻohana i kahi teaspoon home e ana i ka hopena. E kuapo i kēlā me kēia syringe waha ma hope o ka hoʻohana ʻana iā ia no 7 mau lā a i ʻole inā ua pōʻino. E hāhai i nā ʻōkuhi a ka mea hana e pili ana i ka hoʻohana a hoʻomaʻemaʻe i ka ʻekekoke waha. E noi i kāu kauka a kauka paha inā ʻoe he nīnau.

Inā ʻoe e hāʻawi ana i ka hopena i kahi keiki, kau i ka piko o ka syringe waha i ka waha o ke keiki e kūʻē i ka ʻaoʻao o ka papalina. E mālama i ke keiki i kahi kū i luna no kekahi mau minuke pono ma hope o ka hāʻawi ʻana i kahi lāʻau o larotrectinib. Inā kuha ke keiki i kahi lāʻau a ʻaʻole ʻoe e ʻike i ka hāʻawi ʻia ʻana o ka mahele lāʻau, mai hāʻawi i kahi lāʻau ʻē aʻe.

Inā luaʻi koke ʻoe ma hope o ka lawe ʻana i ka larotrectinib, mai hana hou i ka lāʻau. E hoʻomau i kāu papa hana maʻamau.

Pono paha kāu kauka e hoʻopau i kahi manawa a kūpaʻa mau paha i kāu lāʻau a hōʻemi paha i kāu lāʻau o larotrectinib i kāu wā e lapaʻau ai. Aia kēia i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a me nā hopena ʻē aʻe āu e ʻike ai. E hoʻomaopopo pono e haʻi aku i kāu kauka i kou ʻano i kou wā e mālama ai me larotrectinib.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i larotrectinib,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka larotrectinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o nā capsule larotrectinib a i ʻole ka hopena. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: kekahi antifungals e like me itraconazole (Onmel, Sporanox) a me ketoconazole; avanafil (Stendra); buspirone; clarithromycin (Biaxin, i PrevPac); kekahi mau lāʻau no ka maʻi pale maʻi (HIV) a i ʻole loaʻa i ka maʻi maʻi maʻi maʻi (AIDS) e like me efavirenz (Sustiva, i Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ma Kaletra), a saquinavir (Hoʻokele); kekahi mau lāʻau e kāohi i ka ʻōnaehana pale e like me everolimus (Afinitor, Zortress), sirolimus (Rapamune), a me tacrolimus (Astagraf, Envarsus XR, Prograf); lovastatin; midazolam; nefazodone; pioglitazone (Actos); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ma Rifamate, ma Rifater); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Carbatrol, Epitol, Tegretol, a me nā mea ʻē aʻe), phenobarbital, a me phenytoin (Dilantin, Phenytek); sildenafil (Revatio, Viagra), simvastatin (Flolipid, Zocor); a me vardenafil (Levitra, Staxyn). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me larotrectinib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St. Mai lawe iā St. John's wort ʻoiai e lawe ana i ka larotrectinib.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa i nā kūlana e hoʻopili i ka ʻōnaehana a me nā maʻi ate.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i ka hānau keiki ʻana. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o kou hoʻomaka ʻana i ka lāʻau a hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā lapaʻau a no 1 pule ma hope o kāu hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā wahine e hoʻohana i ka kaohi hānau ma kāu wā e mālama ai a no 1 mau pule ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana. Hiki i ka Larotrectinib ke hoʻemi i ka momona i nā wahine. Eia naʻe, ʻaʻole pono ʻoe e kuhi ʻaʻole hiki iā ʻoe ke hāpai. Inā hāpai ʻoe a ʻo kāu hoa paha, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Larotrectinib i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻAʻole pono ʻoe e hānai i ka wā o kāu mālama ʻana a no 1 mau pule ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike i ka larotrectinib hiki ke hoʻoulu i ka hiamoe, lōlō, a huikau paha. Mai hoʻokele i kahi kaʻa a hana i nā mīkini a ʻike ʻoe i ka hopena o kēia lāʻau iā ʻoe.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā ʻoi aku ia ma mua o 6 mau hola ma mua o kāu mahele aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hana ʻo Larotrectinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻūhā
• kōpaʻa
• pāhoehoe
• nausea
• ka luaʻi
• ʻeha ka ʻōpū
• ʻeha poʻo
• paheʻe ihu
• loaʻa kaupaona
• Muscle, ami, a ʻeha hoʻi
• nāwaliwali o nā mākala
• hoʻonui i ka make wai; hoʻololi i ka nui a me ke kala o ka mimi; ʻili maloʻo; a maule paha

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole kēlā mau mea i ka ʻĀKAHI MAKAHIKI ʻāpana, e kelepona koke i kāu kauka a i ʻole e kiʻi i nā lāʻau lapaʻau pilikia

• lohi a paʻakikī paha i ka ʻōlelo; hāʻule pōʻino ʻole; a i ʻole ke kani ʻana, ka helu ʻana, a i ʻole ka ʻā ʻana o ke ahi i kou mau lima a me kou mau wāwae
• fiva
• pehu i nā lima, nā wāwae, nā kuʻekuʻe wāwae, a i nā wāwae lalo
• pokole o ka hanu
• luhi ʻole a palupalu paha; a i ʻili pale
• lilo o ka makemake ʻole; nausea; ka luaʻi; melemele o ka ʻili a i ʻole nā ​​maka; aiʻole kaʻeha ma kaʻaoʻao'ākau o luna o ka'ōpū

Hiki i nā Larotrectinib ke hana i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama i nā capsule i ka mahana wela a mamao aku i ka wela a me ka makū (ʻaʻole i loko o ka lua. E mālama i ka hopena waha i loko o ka pahu hau a paʻa paʻa; mai paʻa hau. E hoʻolei i kahi haʻina waha i hoʻohana ʻole ʻia 90 mau lā ma hope o ka wehe ʻana o ka ʻōmole no ka manawa mua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i ka wā o ka mālama ʻana e nānā i ka pane o kou kino i larotrectinib. No kekahi mau kūlana, e kauoha kāu kauka i kahi hoʻokolohua hoʻokolohua ma mua o kou hoʻomaka ʻana i kāu lāʻau e ʻike inā hiki ke mālama ʻia i kou maʻi ʻaʻai me larotrectinib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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