Ribociclib

Anter

• Ma mua o ka lawe ʻana i ribociclib,
• Hoʻokumu paha ʻo Ribociclib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

Hoʻohana ʻia ʻo Ribociclib me ka lāʻau lapaʻau ʻē aʻe e mālama ai i kekahi ʻano o ka receptor hormone – maikaʻi (pili i nā hormoni e like me ka ulu ʻana o ka estrogen) ua loaʻa ka maʻi ʻaʻai umauma holomua a i ʻole pālahalaha ʻia i nā ʻāpana ʻē aʻe o ke kino i nā wahine i ʻike ʻole i ka menopause (hoʻololi o ke ola; ka pau ʻana o nā wā menstrual o ka mahina) a i ka poʻe kokoke a i ʻole ua ʻike i ka menopause. Hoʻohana ʻia ʻo Ribociclib me ka hui pū me fulvestrant (Faslodex) e mālama i kekahi ʻano o ka receptor hormone – ʻo ka maʻi ʻaʻai umauma holomua a i ʻole pālahalaha ʻia i nā ʻāpana ʻē aʻe o ke kino ma ke ʻano he lapaʻau mua a i ʻole i ka poʻe i mālama maikaʻi ʻole ʻia me nā lāʻau ʻē aʻe. i nā wahine i ʻike mua i ka menopause. Aia ʻo Ribociclib i kahi papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kahi protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hoʻolohi a hoʻopau paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Ribociclib ma ke ʻano he papa e lawe ma ka waha. Lawe pinepine ʻia me a me ka ʻole o ka meaʻai i kēlā me kēia lā i ke kakahiaka no nā lā 21 mua o kahi pōʻaiapuni 28 mau lā. Lawe i ka ribociclib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pololei i ka ribociclib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou. Mai lawe i nā papa i haki a haki paha.

Inā luaʻi ʻoe ma hope o ka lawe ʻana i ka ribociclib, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau o ribociclib a i ʻole kūlohi a kūloko paha i kāu lāʻau. Aia kēia i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a me nā hopena ʻē aʻe āu e ʻike ai. E haʻi pono i kāu kauka i kou ʻano i kou wā e mālama ai me ribociclib.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ribociclib,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka ribociclib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa ribociclib E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E haʻi pono i kekahi o kēia mau mea: amiodarone (Nexterone, Pacerone); kekahi mau antibiotic e like me clarithromycin (Biaxin, in Prevpac), erythromycin (E.E.S., Ery-tab, Eryped), a me moxifloxacin (Avelox); kekahi mau lāʻau lapaʻau antifungal e like me itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), a me voriconazole (Vfend); bepridil (ʻaʻole loaʻa hou ma U.S.); boceprevir (Victrelis, ʻaʻole loaʻa hou ma U.S.); chloroquine (Aralen); konivaptan; cyclosporine (Gengraf, Neoral, Sandimmune); dihydroergotamine (D.H.E. 45, Migranal); disopyramide (Norpace); ergotamine (Ergomar, ma Cafergot, ma Migergot); everolimus (Afinitor, Zortress); fentanyl (Abstral, Actiq, Fentora, Onsolis); halofantrine (Halfan; ʻaʻole i loaʻa hou ma U.S.); haloperidol (Haldol); kekahi mau lāʻau no ka maʻi pale maʻi (HIV) e like me efavirenz (Sustiva, i Atripla), indinavir (Crixivan), lopinavir (i Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ma Kaletra), a me saquinavir (Invirase); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Carbatrol, Equetro, Teril, a me nā mea ʻē aʻe) a me phenytoin (Dilantin, Phenytek); methadone (Dolophine, Methadose); nefazodone; ondansetron (kū i loko); pimozide (Orap); procainamide; quinidine (i Nuedexta); rifampin (Rimactane, Rifadin, ma Rifamate, ma Rifater); sirolimus (Rapamune); sotalol (Betapace, Sotylize); tacrolimus (Envarsus XR, Prograf), a me tamoxifen (Soltamox). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.Nui paha nā lāʻau ʻē aʻe e launa pū paha me ribociclib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo keu ʻo St. John's Wort.
• e haʻi i kāu kauka inā loaʻa ʻoe i kahi puʻuwai puʻuwai hou loa; a i ʻole ua loaʻa paha i kahi puʻuwai puʻuwai lohi; kahi wā QT hoʻolōʻihi (kahi pilikia puʻuwai laha ʻole e hiki ai ke hōʻeha i ka puʻuwai ʻole, maʻule, a make koke paha); nā pae maʻamau o ka potassium, calcium, phosphorus, a me magnesium i loko o kou koko; puʻuwai puʻuwai; a i ʻole ate, hakuʻala, a maʻi maʻi puʻuwai paha.
• e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. Pono ʻoe e lawe i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau. E hoʻohana i kahi ʻano pono o ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā e mālama ai a no 3 mau pule ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu. Inā hāpai ʻoe i ka lawe ʻana i ribociclib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Ribociclib i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū a i ʻole hoʻolālā e hānai. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana i ka ribociclib a no ka liʻiliʻi he 3 mau pule ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne. E kamaʻilio me kāu kauka e pili ana i ka makaʻu i ka lawe ʻana i ribociclib.
• inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o ka niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe ana ʻoe i ka ribociclib.

Mai ʻai i ka hua waina a inu hoʻi i ka huaʻōlō i ka lawe ʻana i kēia lāʻau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Ribociclib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• pāhoehoe
• kōpaʻa
• ʻeha ka ʻōpū
• ʻeha poʻo
• poho lauoho
• ʻeha kua
• ʻūlili
• ʻeha nā waha
• ka pehu o nā lima, ka wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
• paʻakikī e hiamoe a hiamoe paha

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

• fiva, ʻeha ka ʻāʻī, haʻalulu, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• hūwī
• ʻele a ʻili paha o ka ʻili
• lapalapa ʻana a ʻāha paha o nā lehelehe, maka, a waha paha
• wikiwiki, kūlike ʻole, a kuʻi paha i ka puʻuwai puʻuwai
• pilikia i ka hanu ʻana a i ʻole ka liʻiliʻi o ka hanu; uha me ka ʻole o ka hemo; a ʻehaʻeha paha
• ʻūpā
• maule ana
• melemele o ka ʻili a me nā maka
• mimi ʻeleʻele a ʻeleʻele (ti-kala)
• luhi
• nalo ʻai ʻole
• ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū
• nausea
• ka luaʻi
• ke kahe ʻana a i ʻole ka palu maʻalahi ʻana ma mua o ka maʻamau

Hoʻokumu paha ʻo Ribociclib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino i ribociclib. Hiki paha i kāu kauka ke kauoha i kahi electrocardiogram (ECG; hoʻāʻo e ana i ka hana uila i ka puʻuwai) ma mua a i kāu wā e lapaʻau ai.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Kisqali^®

• Kisqali^® Femera^® (ma ke ʻano he huahana hoʻohui ʻia me Letrazole a me Ribociclib)