ʻO Lopinavir lāua ʻo Ritonavir

Anter

• Ma mua o ka lawe ʻana i ka lopinavir a me ka ritonavir,
• Lopinavir a ritonavir paha i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Ke aʻo ʻia nei ʻo Lopinavir a me ritonavir i kekahi mau noiʻi noiʻi e hoʻomau nei no ka mālama ʻana i ka maʻi coronavirus 2019 (COVID-19) a i ʻole me nā lāʻau ʻē aʻe. ʻO ka hoʻohana ʻana o ka lopinavir a me ritonavir no ka mālama ʻana i COVID-19 ʻaʻole i hoʻokumu ʻia. Lana ka manaʻo o kekahi poʻe ʻepekema no ka mea ua hoʻohana ʻia kēia mau lāʻau e mālama ai i nā maʻi viral like.

Lopinavir a ritonavir e lawe WALE ma lalo o ke alakaʻi a ke kauka no ka mālama ʻana iā COVID-19.

Hoʻohana ʻia ka hui pū ʻana o ka lopinavir a me ritonavir me nā lāʻau ʻē aʻe e mālama ai i ka maʻi maʻi maʻi maʻi (HIV). ʻO Lopinavir a me ritonavir i kahi papa o nā lāʻau i kapa ʻia nā protease inhibitors. Hana lākou ma ka hōʻemi ʻana i ka nui o ka maʻi HIV i loko o ke koko. Ke lawe pū ʻia ʻo lopinavir a me ritonavir, kōkua pū ʻo ritonavir e hoʻonui i ka nui o ka lopinavir i ke kino i mea e ʻoi aku ka hopena o ka lāʻau. ʻOiai ʻaʻole e hoʻōla ka lopinavir a me ritonavir i ka maʻi HIV, hiki i kēia mau lāʻau ke hoʻoliʻiliʻi i kou manawa kūpono e hoʻomohala i loaʻa i ka maʻi i loaʻa i ka maʻi maʻi (AIDS) a me nā maʻi e pili ana i ka maʻi HIV e like me nā maʻi ʻino a i ʻole ka maʻi ʻaʻai. ʻO ka lawe ʻana i kēia mau lāʻau a me ka hoʻomaʻamaʻa ʻana i ka moekolohe ʻoi aku ka maikaʻi a me ka hoʻololi ʻana i ke ʻano ola ʻē aʻe e hōʻemi paha i ka lawe ʻana i ka maʻi HIV i kekahi poʻe ʻē aʻe.

ʻO ka hui pū ʻana o ka lopinavir a me ka ritonavir e hiki mai ana ma ke ʻano he papa a me kahi hopena (wai) e lawe ʻia e ka waha. Lawe ʻia ia i ʻelua mau manawa i ka lā, akā lawe ʻia i hoʻokahi manawa i ka lā e kekahi poʻe mākua. Pono e lawe i ka hopena me ka meaʻai. Lawe ʻia nā papa me ka ʻai ʻole. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E lawe pono i ka lopinavir a me ka ritonavir. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.

Inā ʻoe e hoʻohana nei i ka hopena, hoʻoluliluli maikaʻi ia ma mua o kēlā me kēia hoʻohana e kāwili kaulike i ka lāʻau. E hoʻohana i ka puna o ka ana ʻana a me ke kīʻaha e ana i ka nui kūpono o ka wai no kēlā me kēia kaha, ʻaʻole kahi puna o ka home.

E hoʻomau i ka lawe ʻana i ka lopinavir a me ritonavir ʻoiai inā ʻoluʻolu ʻoe. Mai hōʻoki i ka lawe ʻana i ka lopinavir a me ritonavir me ke kamaʻilio ʻole ʻana me kāu kauka. Inā haʻalele ʻoe i nā lāʻau, lawe i ka mea i hoʻākoakoa ʻia, a i ʻole ka hoʻoki ʻana i ka lawe ʻana i ka lopinavir a me ritonavir, e ʻoi aku ka paʻakikī o kou ʻano e mālama.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka lopinavir a me ka ritonavir,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka lopinavir, ritonavir (Norvir), nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hoʻohui i ka lopinavir a me nā ritonavir papa a i ʻole ka hopena. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka inā lawe ʻoe i kekahi o nā lāʻau aʻe: alfuzosin (Uroxatral); apalutamide (Erleada); cisapride (Propulsid) (ʻaʻole loaʻa ma ka U.S.); colchisin (Colcrys, Mitigare) i ka poʻe me nā puʻupaʻa a me nā maʻi ate paha; dronedarone (Multaq); elbasvir and grazoprevir (Zepatier); nā lāʻau lapaʻau ergot e like me dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, ma Cafergot, ma Migergot), a me methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); lawe ʻia ʻo midazolam e ka waha (Versed); pimozide (Orap); ranolazine (Ranexa); rifampin (Rimactane, Rifadin, ma Rifamate, ma Rifater); sildenafil (ʻo ka inoa Revatio wale nō i hoʻohana ʻia no ka maʻi puʻupuʻu); simvastatin (Zocor, i Vytorin); St. John's wort; aiʻole triazolam (Halcion). E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka lopinavir a me ritonavir inā ʻoe e lawe i hoʻokahi a ʻoi paha o kēia mau lāʻau.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā huaora, a me nā mea hoʻopono pono ʻē aʻe āu e lawe nei. E hoʻomaopopo pono e ʻōlelo i kekahi o kēia mau mea: anticoagulants ('blood thinners') e like me warfarin (Coumadin, Jantoven) a me rivaroxaban (Xarelto); nā antifungals e like me itraconazole (Onmel, Sporanox), isavuconazonium (Cresemba), ketoconazole (Nizoral), a me voriconazole (Vfend); atovaquone (Mepron, ma Malarone); bedaquiline (Sirturo); beta-blockers; bosentan (Tracleer); bupropion (Wellbutrin, Zyban, haʻi ʻē aʻe); nā poloka calcium-channel e like me felodipine, nicardipine (Cardene), a me nifedipine (Adalat, Afeditab CR, Procardia); nā lāʻau hoʻohaʻahaʻa kolesterol e like me atorvastatin (Lipitor, ma Caduet), a me rosuvastatin (Crestor); clarithromycin (Biaxin, i Prevpac); digoxin (Lanoxin); elagolix (Orilissa); fentanyl (Actiq, Duragesic, Onsolis, nā mea ʻē aʻe); fosamprenavir (Lexiva); kekahi mau lāʻau no ka maʻi ʻaʻai e like me abemaciclib (Verzenio), dasatinib (Sprycel), encorafenib (Braftovi), ibrutinib (Imbruvica), ivosidenib (Tibsovo), neratinib (Nerlynx), nilotinib (Tasigna), venetoclax (Venclexta), vinblastine ; kekahi mau lāʻau no ke kuʻi puʻuwai ʻole e like me amiodarone (Cordarone, Nexterone, Pacerone), bepridil (ʻaʻole loaʻa hou ma US; Vascor), tutupocaine (Lidoderm; i Xylocaine me Epinephrine), a me quinidine (i Nuedexta); kekahi mau lāʻau no ka maʻi hepatitis C (HCV) e like me boceprevir (Victrelis; ʻaʻole loaʻa hou ma U.S.); glecaprevir a me pibrentasvir (Mavyret); simeprevir (ʻaʻole loaʻa hou ma U.S.; Olysio); sofosbuvir, velpatasvir, a me voxilaprevir (Sovaldi, Epclusa, Vosevi); a me paritaprevir, ritonavir, ombitasvir, a me / a i ʻole dasabuvir (Viekira Pak); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Equetro, Tegretol, Teril, a me nā mea ʻē aʻe), lamotrigine (Lamictal), phenobarbital, phenytoin (Dilantin, Phenytek), a me valproate; nā lāʻau e kāohi i ka ʻōnaehana pale e like me cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), a me tacrolimus (Astagraf, Prograf); methadone (Dolophine, Methadose); nā steroid a waha a ʻone paha e like me betamethasone, budesonide (Pulmicort), cicleonide (Alvesco, Omnaris), dexamethasone, fluticasone (Flonase, Flovent, i Advair), methylprednisolone (Medrol), mometasone (i Dulera). prednisone (Rayos), a me triamcinolone; nā lāʻau antiviral ʻē aʻe e like me abacavir (Ziagen, ma Epzicom, ma Trizivir, a me nā mea ʻē aʻe); atazanavir (Reyataz, in Evotaz), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), indinavir (Crixivan), maraviroc (Selzentry), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra) (Viread, ma Atripla, ma Truvada), tipranavir (Aptivus), saquinavir (Invirase), a me zidovudine (Retrovir, ma Combivir, ma Trizivir); quetiapine (Seroquel); rifabutin (Mycobutin); salmeterol (Serevent, ma Advair); sildenafil (Viagra); tadalafil (Adcirca, Cialis); trazodone; a me vardenafil (Levitra). Inā ʻoe e lawe i ka hopena waha, haʻi pū i kāu kauka inā lawe ʻoe disulfiram (Antabuse) a i ʻole metronidazole (Flagyl, ma Nuvessa, ma Vandazole). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• inā ʻoe e lawe ana i ka didanosine, lawe ia i hoʻokahi hola ma mua a i ʻole 2 mau hola ma hope o kou lawe ʻana i ka hopena lopinavir a ritonavir me ka meaʻai. Inā ʻoe e lawe i nā papa lopinavir a ritonavir, lawe paha ʻoe iā lākou ma kahi ʻōpū nele i ka manawa like me ʻoe e lawe ai i ka didanosine.
• e haʻi i kāu kauka inā loaʻa a i ʻole loaʻa i kahi wā QT hoʻolōʻihi (kahi pilikia puʻuwai laha ʻole e hiki ai ke hōʻeha i ka puʻuwai ʻole, maʻule, a make koke paha), kahi puʻuwai puʻuwai ʻole, kahi pae haʻahaʻa o ka potassium i loko o kou koko, hemophilia, kolesterol kiʻekiʻe a triglycerides (momona) i loko o ke koko, pancreatitis (hāhā o ka pancreas), a i ʻole ka maʻi puʻuwai a i ʻole ate.
• pono ʻoe e ʻike i ka lopinavir a me ka ritonavir e hoʻemi ai i ka pono o nā kaola pale hormonal (nā lāʻau kaohi hānau, nā pā, nā apo, a i ʻole nā ​​injection). E kamaʻilio me kāu kauka e pili ana i ka hoʻohana ʻana i kahi ʻano o ka kaohi hānau.
• e haʻi i kāu kauka inā hāpai ʻoe, hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka lopinavir a me ritonavir, e kāhea i kāu kauka. ʻAʻole pono ʻoe e hānai i ka umauma inā loaʻa ʻoe i ka maʻi HIV a i ʻole inā lawe ʻoe i ka lopinavir a me ka ritonavir.
• pono ʻoe e ʻike i kekahi mau mea hoʻohui i ka hopena lopinavir a ritonavir i kumu i nā hopena ʻino a hoʻoweliweli hoʻi i nā pēpē hānau hou. ʻAʻole pono e hāʻawi ʻia ka hopena waha ʻo Lopinavir a me ritonavir i nā pēpē wā piha ma mua o 14 mau lā a i ʻole nā ​​pēpē ʻōpio ma mua o 14 mau lā i hala i ko lākou lā kumu mua, ke ʻole inā manaʻo kahi kauka he kumu kūpono no ka loaʻa ʻana o ka lāʻau i ka pēpē. ma hope o ka hānau ʻana. Inā koho ke kauka o kāu pēpē e hāʻawi i kāu pēpē lopinavir a me ka ritonavir hopena ma hope koke o ka hānau ʻana, e nānā pono ʻia kāu pēpē no nā hōʻailona o nā hopena koʻikoʻi. Kāhea koke i ke kauka o kāu pēpē inā hiamoe nui kāu pēpē a i ʻole he loli i ka hanu ʻana i ka wā o kāna mālama ʻana me ka lopinavir a me ka ritonavir oral solution.
• e hoʻomaopopo ʻoe i ka momona o kou kino e hoʻonui a neʻe paha i nā wahi like ʻole o kou kino, e like me kou kua i luna, ʻāʻī ('' buffalo hump ''), nā umauma, a puni kou ʻōpū. ʻIke paha ʻoe i ka nalo ʻana o ka momona o ke kino mai kou alo, mau wāwae, a me kou mau lima.
• pono ʻoe e ʻike e ʻike paha ʻoe i ka hyperglycemia (hoʻonui i kāu kō kō) ʻoiai ʻoe e lawe nei i kēia lāʻau, ʻoiai inā ʻaʻohe ou diabetes. E haʻi koke i kāu kauka inā loaʻa iā ʻoe kekahi o nā ʻōuli aʻe ke lawe nei ʻoe i ka lopinavir a me ka ritonavir: make wai loa, mimiki pinepine, pōloli loa, ʻike maka ʻole, a nāwaliwali paha. He mea nui ia e kāhea aku i kāu kauka ke loaʻa koke iā ʻoe kekahi o kēia mau ʻōuli, no ka mea, ʻaʻole mālama ʻia ke kō koko kiʻekiʻe e mālama ʻia ai i kahi ʻano koʻikoʻi i kapa ʻia ʻo ketoacidosis. Lilo paha ʻo Ketoacidosis i mea hoʻoweliweli i ke ola ke mālama ʻole ʻia ia i ka wā mua. ʻO nā ʻōuli o ketoacidosis e komo pū me: waha maloʻo, nausea a me ka luaʻi, ka hanu o ka hanu, ka hanu e ʻaʻala i ka hua, a me ka emi o ka ʻike.
• pono ʻoe e ʻike ʻoiai ʻoe e lawe nei i nā lāʻau e mālama ai i ka maʻi HIV, e ikaika paha kou ʻōnaehana pale a hoʻomaka e hakakā i nā maʻi ʻē aʻe i loko o kou kino. Hiki iā ʻoe ke hoʻomohala i nā ʻōuli o kēlā mau maʻi. Inā loaʻa iā ʻoe nā hōʻailona hou a pōʻino paha ma hope o ka hoʻomaka ʻana o ka mālama ʻana me lopinavir a me ritonavir, e haʻi pono i kāu kauka.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Lopinavir a ritonavir paha i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• nāwaliwali
• pāhoehoe
• ʻenekini
• puʻuwai puʻuwai
• Kaumaha emi
• ʻeha poʻo
• paʻakikī e hiamoe a hiamoe paha
• ʻeha mākala
• numbness, puhi ʻana, a i ʻole ka ʻūlū ʻana i nā lima a me nā wāwae paha
• ʻeha o ka ʻōpū, nausea, a me ka luaʻi

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• nausea
• ka luaʻi
• ʻeha ka ʻōpū
• luhi loa
• nalo ʻai ʻole
• ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū
• melemele o ka ʻili a me nā maka
• ʻili ʻili
• ʻūpā
• ʻālohilohi
• maule ana
• kuʻi puʻuwai ʻole
• ʻōhū
• hūwī

ʻO Lopinavir a ritonavir paha ke kumu o nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama i nā papa i ka mahana o ka lumi a pale iā lākou mai ka momona. ʻOi aku ka maikaʻi e mālama i nā papa i loko o ka pahu i komo mai lākou; inā pono ʻoe e lawe iā lākou i waho o ka ipu, pono ʻoe e hoʻohana iā lākou ma waena o 2 mau pule. Hiki iā ʻoe ke mālama i ka hopena waha i loko o ka pahu hau a hiki i ka lā palena pau i paʻi ʻia ma ka lepili, a i ʻole mālama ʻoe iā ia i ka mahana wela no 2 mau mahina.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

He mea nui ia e kiʻi koke i ke kōkua olakino inā inu ke keiki ma mua o ka maʻa mau o ka hopena. Loaʻa i ka hopena ka nui o ka waiʻona a me nā mea hana ʻē aʻe i hiki ke hōʻeha loa i kahi keiki.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino i ka lopinavir a me ka ritonavir.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Kaletra^® (me Lopinavir, Ritonavir)